Ko Kwonmok, Carter Ben, Cleare Anthony J, Rucker James J
Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
Neuropsychiatr Dis Treat. 2023 Oct 5;19:2105-2113. doi: 10.2147/NDT.S426193. eCollection 2023.
In psychedelic therapy, mystical as well as challenging experience may influence therapeutic outcome. However, predictors of such experience have not been sufficiently established. Determining predictors of their intensity is, therefore, potentially beneficial in targeting psilocybin therapy for depression.
In a post hoc data analysis of a Phase 1, randomised, double-blind, placebo-controlled, between-groups clinical trial, dosage, personality traits, affect, and individual data were analysed as possible clinical predictors. Eighty-nine healthy volunteers were randomised to receive a single dose of placebo, 10 mg of psilocybin, or 25 mg of psilocybin. ANOVA was used to analyse the relationship between dosage and mystical and/or challenging experience, and correlation analysis for all other variables.
The intensity of both mystical and challenging experience was strongly associated with higher dosage. Age was negatively correlated with intensity of challenging experience. Correlation between identified personality traits and either mystical or challenging experience was minimal, with the exception of positive correlation between neuroticism and challenging experience at higher dose. Neither positive nor negative affect indicated correlation with the intensity of either type of experience.
A limitation of this study is its post hoc, exploratory design; recommendations for further research are provided.
在迷幻疗法中，神秘体验以及具有挑战性的体验可能会影响治疗效果。然而，此类体验的预测因素尚未得到充分确立。因此，确定其强度的预测因素可能有助于针对抑郁症开展裸盖菇素疗法。
在一项1期随机双盲安慰剂对照组间临床试验的事后数据分析中，对剂量、人格特质、情感及个体数据作为可能的临床预测因素进行分析。89名健康志愿者被随机分配接受单剂量安慰剂、10毫克裸盖菇素或25毫克裸盖菇素。采用方差分析来分析剂量与神秘及/或具有挑战性体验之间的关系，并对所有其他变量进行相关分析。
神秘体验和具有挑战性体验的强度均与较高剂量密切相关。年龄与具有挑战性体验的强度呈负相关。除了在较高剂量下神经质与具有挑战性体验呈正相关外，所确定的人格特质与神秘或具有挑战性体验之间的相关性极小。积极情感和消极情感均未显示与任何一种体验类型的强度存在相关性。
本研究的一个局限性在于其事后探索性设计；文中提供了进一步研究的建议。
