Departments of Medicine, Division of Geriatrics and Gerontology.
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI.
Alzheimer Dis Assoc Disord. 2023;37(4):282-289. doi: 10.1097/WAD.0000000000000586. Epub 2023 Oct 12.
As Alzheimer disease (AD) biomarker testing becomes more widely available, adults may opt to learn results. Considering potential reactions to learning biomarker results can guide prebiomarker and postbiomarker testing education and counseling programs.
Cognitively healthy adults enrolled in observational Alzheimer research responded to a telephone survey about learning AD risk information (n=334; 44% Black or African American; mean age=64.9±7.0). Multiple linear regression models tested if contextual factors predicted anticipated psychological impact (distress, stigma, and cognitive symptoms) or behavior change (planning and risk-reduction). Secondary analyses tested for differences in relationships by racial identity.
Internal health locus of control, concern about AD, self-identified sex, education, family dementia history, and belief in AD modifiability predicted anticipated psychological impact. Concern about AD, age, racial identity, belief in AD modifiability, research attitudes, and exposure to brain health-related social norms predicted anticipated behavior change. For Black respondents, there were no sex differences in anticipated distress, whereas there were stronger relationships between health locus of control, brain health social norms, and education on outcomes compared with White respondents.
Results may inform personalized and culturally tailored biomarker testing education and counseling to minimize psychological impacts and increase behavior change related to learning AD risk information.
随着阿尔茨海默病（AD）生物标志物检测的应用越来越广泛，成年人可能会选择了解检测结果。考虑到对学习生物标志物结果的潜在反应，可以为预生物标志物和后生物标志物检测教育和咨询计划提供指导。
参与阿尔茨海默病观察性研究的认知健康成年人通过电话调查回答了有关学习 AD 风险信息的问题（n=334；44%为黑种人或非裔美国人；平均年龄=64.9±7.0）。多线性回归模型检验了情境因素是否预测了预期的心理影响（困扰、污名和认知症状）或行为改变（计划和降低风险）。二次分析检验了种族认同差异对关系的影响。
内部健康控制源、对 AD 的关注、自我认定的性别、教育、家族痴呆史和对 AD 可修饰性的信念预测了预期的心理影响。对 AD 的关注、年龄、种族认同、对 AD 可修饰性的信念、研究态度和对大脑健康相关社会规范的接触预测了预期的行为改变。对于黑人受访者，在预期困扰方面没有性别差异，而与白人受访者相比，健康控制源、大脑健康社会规范和教育对结果的关系更强。
研究结果可能为个性化和文化适应的生物标志物检测教育和咨询提供信息，以最大程度地减少与学习 AD 风险信息相关的心理影响，并增加行为改变。
