School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, Institutes of Physical Science and Information Technology, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei 230601, P. R. China.
School of Materials Science and Engineering, School of Chemistry and Chemical Engineering, Institutes of Physical Science and Information Technology, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei 230601, P. R. China.
Anal Chem. 2023 Oct 24;95(42):15636-15644. doi: 10.1021/acs.analchem.3c02777. Epub 2023 Oct 12.
The uncontrollable distribution of antitumor agents remains a large obstacle for specific and efficient cancer theranostics; thus, efficient construction of tumor-specific systems is highly desirable. In this work, a general design of tumor stimulus-activatable pretheranostic agents was put forward via a series of structures-tunable triphenylamine derivatives (, , and ) with phenothiazine, benzothiazine, and thiomorpholine as identifying groups of hypochlorite (HClO), respectively. Notably, the sulfur atom in phenothiazine of was more easily oxidized to sulfoxide groups by HClO, transforming into an electron acceptor to form an excellent push-pull electronic system, which was beneficial to a large redshift of absorbance and emission wavelengths. Based on this, resorted to a key of overexpressed HClO in the tumor to open "three locks", viz, NIR fluorescence, photothermal, and photoacoustic signals for multimodal diagnostic and treatment of the tumor. This study provided an elegant design to adopt tumor stimulus-triggerable pretheranostic for improving theranostic accuracy and efficiency, which was regarded as a promising candidate for precision medicine.
抗肿瘤药物的不可控分布仍然是特异性和高效癌症治疗学的一大障碍；因此，高效构建肿瘤特异性系统是非常需要的。在这项工作中，通过一系列结构可调的三苯胺衍生物（、、和），分别以吩噻嗪、苯并噻嗪和硫代吗啉作为次氯酸盐（HClO）的识别基团，提出了一种肿瘤刺激激活前治疗剂的通用设计。值得注意的是，中的吩噻嗪中的硫原子更容易被 HClO 氧化成亚砜基团，转化为电子受体，形成一个极好的推拉电子系统，有利于吸收和发射波长的大幅红移。基于这一点，通过肿瘤中超表达 HClO 来打开“三把锁”，即近红外荧光、光热和光声信号，用于肿瘤的多模态诊断和治疗。这项研究为采用肿瘤刺激触发前治疗提供了一种优雅的设计，以提高治疗的准确性和效率，被认为是精准医学的一个有前途的候选者。
