Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan.
Hypertens Res. 2023 Dec;46(12):2670-2678. doi: 10.1038/s41440-023-01455-z. Epub 2023 Oct 12.
Smoking is associated with vascular endothelial dysfunction. It is thought that smoking impairs vascular endothelial function through a decrease in nitric oxide bioavailability induced by activation of oxidative stress and inflammation. Endothelial dysfunction can be improved or augmented by appropriate interventions including pharmacotherapy, administration of supplements and lifestyle modifications. Although there have not been many studies, the effects of smoking cessation on endothelial function have been shown. In those studies, it was shown that smoking cessation does not always have a positive effect on vascular endothelial function. In this review, I will focus on the role of smoking in endothelial function and the effects of smoking cessation on endothelial function. Smoking impairs vascular endothelial function and leads to atherosclerosis. Smoking cessation is expected to improve vascular endothelial function. Effects of smoking cessation on endothelial function are not always consistent. Further studies are needed to determine whether smoking cessation directly improves endothelial function. NO indicates nitric oxide.
吸烟与血管内皮功能障碍有关。人们认为，吸烟通过激活氧化应激和炎症导致的一氧化氮生物利用度降低，损害血管内皮功能。适当的干预措施，包括药物治疗、补充剂的应用和生活方式的改变，可以改善或增强内皮功能。尽管研究不多，但已经显示出戒烟对内皮功能的影响。在这些研究中，表明戒烟并不总是对血管内皮功能有积极影响。在这篇综述中，我将重点关注吸烟对内皮功能的作用以及戒烟对内皮功能的影响。吸烟损害血管内皮功能，导致动脉粥样硬化。戒烟有望改善血管内皮功能。戒烟对内皮功能的影响并不总是一致的。需要进一步的研究来确定戒烟是否直接改善内皮功能。NO 表示一氧化氮。
