Demir Derya, Toygar Ismail, Soylu Emrah, Aksu Ali Tarık, Türeyen Aynur, Yıldırım Ilgın, Çetinkalp Şevki
Pathology, Ege University, Faculty of Medicine, İzmir, TUR.
Nursing, Muğla Sıtkı Koçman University, Fethiye Faculty of Health Sciences, Muğla, TUR.
Cureus. 2023 Sep 10;15(9):e45001. doi: 10.7759/cureus.45001. eCollection 2023 Sep.
Diabetic foot is a consequential and dangerous complication of diabetes, contributing to decreased quality of life, escalated hospitalizations, and increased mortality rates. Using an experimental model of diabetes, this study aims to investigate the effect of Lavandula stoechas on wound healing.
A total of 35 albino Wistar rats, 250-350 grams in weight, were used. The rats were divided into five groups, seven rats in each group. Of these, 21 rats were induced with 50 mg/kg streptozotocin (STZ) to mimic the diabetic condition. Additionally, 14 rats remained non-diabetic and served as the control group. The diabetic rats were further divided into three subgroups. The non-diabetic group was split into two subgroups based on the dressing materials used (allicin, physiological serum, and control). Wound dimensions were assessed on Days 0, 7, 14, and 21. Biopsies were taken from the wound sites at the same time.
There were significant differences between groups on Days 7, 14, and 21. The percentage of healing was highest in the Lavandula Stoechas group on Days 7, 14, and 21. Microscopic examination of the biopsies supported accelerated wound healing on Days 7 and 14. Reduced mononuclear cell density and increased hair follicle and adipose tissue development were observed in the DM (diabetes mellitus)-Lavandula Stoechas group on Day 7. On Day 14, the DM-Lavandula Stoechas group increased collagen levels and hair follicles. Similarly, the non-DM-Lavandula Stoechas group showed reduced bullae, dermal edema, and intraepithelial edema on Day 7. This was followed by increased fibroblast levels on Day 14.
In conclusion, this study provides compelling evidence for the potential of Lavandula stoechas extract in the enhancement of diabetic wound healing. The multiple interactions revealed here highlight the need for further investigation into the underlying mechanisms. A cost-effective use of Lavandula stoechas opens up promising prospects in managing diabetic foot healing. This warrants additional research and clinical translation.
糖尿病足是糖尿病一种严重且危险的并发症，会导致生活质量下降、住院率上升和死亡率增加。本研究采用糖尿病实验模型，旨在探讨薰衣草对伤口愈合的影响。
共使用35只体重250 - 350克的白化Wistar大鼠。将大鼠分为五组，每组七只。其中，21只大鼠用50毫克/千克链脲佐菌素（STZ）诱导以模拟糖尿病状态。另外，14只大鼠保持非糖尿病状态作为对照组。糖尿病大鼠进一步分为三个亚组。非糖尿病组根据使用的敷料材料（大蒜素、生理血清和对照）分为两个亚组。在第0、7、14和21天评估伤口尺寸。同时从伤口部位取活检组织。
在第第7、14和21天，各组之间存在显著差异。在第7、14和21天，薰衣草组的愈合百分比最高。活检组织的显微镜检查支持在第7和14天伤口愈合加速。在第7天，糖尿病 - 薰衣草组观察到单核细胞密度降低，毛囊和脂肪组织发育增加。在第14天，糖尿病 - 薰衣草组的胶原蛋白水平和毛囊增加。同样，非糖尿病 - 薰衣草组在第7天显示大疱、真皮水肿和上皮内水肿减少。随后在第14天成纤维细胞水平增加。
总之，本研究为薰衣草提取物在促进糖尿病伤口愈合方面的潜力提供了有力证据。这里揭示的多种相互作用凸显了对潜在机制进行进一步研究的必要性。薰衣草的经济有效使用为糖尿病足愈合管理开辟了广阔前景。这值得进一步研究和临床转化。
