Faro Elissa Z, Sauder Katherine A, Norman Gwendolyn S, Anderson Amber, Vélez-Vega Carmen, Napp David, Huddleston Kathi C
Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Department of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Aurora, CO, USA.
J Clin Transl Sci. 2023 Aug 29;7(1):e198. doi: 10.1017/cts.2023.620. eCollection 2023.
Large, transdisciplinary research consortia have increasingly been called upon to address complex and challenging health problems. The National Institutes of Health's (NIH) Environmental influences on Child Health Outcomes (ECHO) Program developed multisite collaboration strategies to promote impactful collaborative observational research on child health. Team science and implementation science offer theoretical and methodological structure to answer questions about the strategies that facilitate successful consortia. We sought to characterize the elements and conditions that influence the implementation of a complex, interdisciplinary longitudinal research program, ECHO.
Informed by the Practical, Robust, Implementation and Sustainability Model, our ethnographic research included semi-structured interviews with internal stakeholders and program evaluation metrics. We conducted template and matrix analysis and triangulated the qualitative and quantitative data to understand the implementation of ECHO.
Between February and May 2022, we conducted 24 virtual interviews with representatives from ECHO components. The main cross-cutting topics that emerged from thematic analysis were collaboration and team science; communication and decision-making; data processes and harmonization; and diversity, equity, and inclusion. Both the qualitative and secondary quantitative evaluation data provided insights into the reach, adoption, implementation, and effectiveness of the program.
A large, multidisciplinary research consortium such as ECHO has produced conceptual, instrumental, capacity building, and connectivity impact for internal and external stakeholders. Facilitators included infrastructure that supported collaboration and learning, alignment of data processes, and harmonization. Opportunities for enhanced impact include multidisciplinary, multimethod communication strategies, and alignment of research priorities.
大型跨学科研究联盟越来越多地被要求应对复杂且具有挑战性的健康问题。美国国立卫生研究院(NIH)的儿童健康结果环境影响(ECHO)项目制定了多地点合作策略,以促进对儿童健康开展有影响力的合作观察性研究。团队科学和实施科学为回答有关促进成功联盟的策略问题提供了理论和方法框架。我们试图描述影响一个复杂的跨学科纵向研究项目ECHO实施的要素和条件。
基于实用、稳健、实施与可持续性模型,我们的人种志研究包括对内部利益相关者的半结构化访谈以及项目评估指标。我们进行了模板和矩阵分析,并对定性和定量数据进行三角互证,以了解ECHO的实施情况。
在2022年2月至5月期间,我们对ECHO各组成部分的代表进行了24次虚拟访谈。主题分析中出现的主要交叉主题是合作与团队科学;沟通与决策;数据流程与协调;以及多样性、公平性和包容性。定性和二次定量评估数据都为该项目的覆盖范围、采用情况、实施情况和有效性提供了见解。
像ECHO这样的大型多学科研究联盟已经为内部和外部利益相关者产生了概念、工具、能力建设和连接方面的影响。促进因素包括支持合作与学习的基础设施、数据流程的一致性以及协调。增强影响力的机会包括多学科、多方法的沟通策略以及研究重点的一致性。