Keighley M R, Thompson H, Moore J, Hoare A M, Allan R N, Dykes P W
Br J Surg. 1979 Apr;66(4):246-7. doi: 10.1002/bjs.1800660408.
A randomized trial has compared the results of brush cytology before or after biopsy in patients with solitary gastric lesions. One hundred and eleven carcinomas were identified in 324 patients. False positive histological reports were recorded in 2 patients but there were no false positive cytology results. The cumulative accuracy of biopsy and cytology in patients with carcinoma was 97 per cent, which was significantly better than biopsy alone (83 per cent, P less than 0.001) or cytology alone (87 per cent, P less than 0.001). The cumulative results of brushing before biopsy were significantly better than results obtained by brushing after biopsy (P less than 0.05) and indicate that brush cytology should normally be performed before biopsy.
一项随机试验比较了孤立性胃病变患者活检前或活检后刷检细胞学检查的结果。324例患者中确诊了111例癌症。有2例患者出现了组织学假阳性报告，但细胞学检查未出现假阳性结果。癌症患者活检和细胞学检查的累积准确率为97%，显著优于单独活检（83%，P<0.001）或单独细胞学检查（87%，P<0.001）。活检前刷检的累积结果显著优于活检后刷检的结果（P<0.05），这表明刷检细胞学检查通常应在活检前进行。
