Inha Research Institute for Aerospace Medicine, Inha University, Incheon 22212, Korea.
Center for Sensor Systems, Inha University, Incheon 22212, Korea.
Int J Mol Sci. 2022 Apr 1;23(7):3946. doi: 10.3390/ijms23073946.
Rare diseases are those which affect a small number of people compared to the general population. However, many patients with a rare disease remain undiagnosed, and a large majority of rare diseases still have no form of viable treatment. Approximately 40% of rare diseases include neurologic and neurodevelopmental disorders. In order to understand the characteristics of rare neurological disorders and identify causative genes, various model organisms have been utilized extensively. In this review, the characteristics of model organisms, such as roundworms, fruit flies, and zebrafish, are examined, with an emphasis on zebrafish disease modeling in rare neurological disorders.
罕见病是指与普通人群相比，影响人数较少的疾病。然而，许多罕见病患者仍未得到诊断，而且大多数罕见病仍然没有可行的治疗方法。大约 40%的罕见病包括神经和神经发育障碍。为了了解罕见神经疾病的特征并确定致病基因，广泛利用了各种模式生物。在这篇综述中，检查了模式生物的特征，如线虫、果蝇和斑马鱼，重点介绍了斑马鱼在罕见神经疾病中的疾病建模。
