Han Jun-Hee, Yoo Dae-Sung, Lee Chang-Min
EpiCentre, School of Veterinary Science, Massey University, Palmerston North 4410, New Zealand.
College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.
Animals (Basel). 2023 Oct 2;13(19):3082. doi: 10.3390/ani13193082.
In December 2014, a novel foot and mouth disease (FMD) virus was introduced to a pig farm in South Korea, despite the animals being vaccinated. A marginal antigenic matching between the novel and vaccine strains potentially led to the infection of the vaccinated animals. To understand the impact of using an FMD vaccine on the transmission dynamics of an unmatched field strain, simulation models were employed using daily reported data on clinical cases from the farm. The results of this study indicated that immunisation with the FMD vaccine reduced the shedding of the novel FMD virus in pigs. However, there was no evidence to suggest that the immunisation had a significant effect in reducing the development of clinical signs. These findings highlight that the use of an unmatched FMD vaccine can confound the outbreak by altering the disease dynamics of the novel virus. Based on this study, we emphasise the importance of continuous testing to ensure antigenic matching between the circulating strains and the vaccine pool.
2014年12月，一种新型口蹄疫（FMD）病毒传入韩国的一个养猪场，尽管这些猪已接种疫苗。新型毒株与疫苗毒株之间的抗原匹配性较差，这可能导致了已接种疫苗的猪被感染。为了解使用口蹄疫疫苗对不匹配的田间毒株传播动态的影响，利用该农场每日报告的临床病例数据建立了模拟模型。本研究结果表明，接种口蹄疫疫苗可减少猪体内新型口蹄疫病毒的 shedding 。然而，没有证据表明免疫接种在减少临床症状的出现方面有显著效果。这些发现突出表明，使用不匹配的口蹄疫疫苗可能会通过改变新型病毒的疾病动态而混淆疫情。基于这项研究，我们强调持续检测以确保流行毒株与疫苗库之间抗原匹配的重要性。
