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使用Transformer网络对小肠胶囊内镜进行视频分析

Video Analysis of Small Bowel Capsule Endoscopy Using a Transformer Network.

作者信息

Oh SangYup, Oh DongJun, Kim Dongmin, Song Woohyuk, Hwang Youngbae, Cho Namik, Lim Yun Jeong

机构信息

School of Electrical and Computer Engineering, Seoul National University, 1 Gwanak-ro, Kwanak-gu, Seoul 08826, Republic of Korea.

Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang 10326, Republic of Korea.

出版信息

Diagnostics (Basel). 2023 Oct 5;13(19):3133. doi: 10.3390/diagnostics13193133.

DOI:10.3390/diagnostics13193133
PMID:37835876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10572266/
Abstract

Although wireless capsule endoscopy (WCE) detects small bowel diseases effectively, it has some limitations. For example, the reading process can be time consuming due to the numerous images generated per case and the lesion detection accuracy may rely on the operators' skills and experiences. Hence, many researchers have recently developed deep-learning-based methods to address these limitations. However, they tend to select only a portion of the images from a given WCE video and analyze each image individually. In this study, we note that more information can be extracted from the unused frames and the temporal relations of sequential frames. Specifically, to increase the accuracy of lesion detection without depending on experts' frame selection skills, we suggest using whole video frames as the input to the deep learning system. Thus, we propose a new Transformer-architecture-based neural encoder that takes the entire video as the input, exploiting the power of the Transformer architecture to extract long-term global correlation within and between the input frames. Subsequently, we can capture the temporal context of the input frames and the attentional features within a frame. Tests on benchmark datasets of four WCE videos showed 95.1% sensitivity and 83.4% specificity. These results may significantly advance automated lesion detection techniques for WCE images.

摘要

尽管无线胶囊内镜(WCE)能有效检测小肠疾病,但它存在一些局限性。例如,由于每个病例生成的图像众多,阅读过程可能很耗时,而且病变检测的准确性可能依赖于操作者的技能和经验。因此,最近许多研究人员开发了基于深度学习的方法来解决这些局限性。然而,他们往往只从给定的WCE视频中选择一部分图像并单独分析每个图像。在本研究中,我们注意到可以从未使用的帧以及连续帧的时间关系中提取更多信息。具体而言,为了在不依赖专家帧选择技能的情况下提高病变检测的准确性,我们建议将整个视频帧作为深度学习系统的输入。因此,我们提出了一种基于Transformer架构的新型神经编码器,它将整个视频作为输入,利用Transformer架构的能力来提取输入帧内和帧之间的长期全局相关性。随后,我们可以捕捉输入帧的时间上下文以及帧内的注意力特征。对四个WCE视频的基准数据集进行的测试显示,灵敏度为95.1%,特异性为83.4%。这些结果可能会显著推进WCE图像的自动病变检测技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0898/10572266/0cc97e6daa1e/diagnostics-13-03133-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0898/10572266/97631baf63a4/diagnostics-13-03133-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0898/10572266/150350f117cc/diagnostics-13-03133-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0898/10572266/90199f496f96/diagnostics-13-03133-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0898/10572266/427c89c2ca87/diagnostics-13-03133-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0898/10572266/99bf1a4513b5/diagnostics-13-03133-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0898/10572266/0cc97e6daa1e/diagnostics-13-03133-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0898/10572266/97631baf63a4/diagnostics-13-03133-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0898/10572266/150350f117cc/diagnostics-13-03133-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0898/10572266/90199f496f96/diagnostics-13-03133-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0898/10572266/427c89c2ca87/diagnostics-13-03133-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0898/10572266/99bf1a4513b5/diagnostics-13-03133-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0898/10572266/0cc97e6daa1e/diagnostics-13-03133-g006.jpg

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本文引用的文献

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Artificial Intelligence in Capsule Endoscopy: A Practical Guide to Its Past and Future Challenges.胶囊内镜中的人工智能:应对其过往与未来挑战的实用指南
Diagnostics (Basel). 2021 Sep 20;11(9):1722. doi: 10.3390/diagnostics11091722.
2
Efficacy of a comprehensive binary classification model using a deep convolutional neural network for wireless capsule endoscopy.基于深度卷积神经网络的综合二进制分类模型在无线胶囊内镜中的疗效。
Sci Rep. 2021 Sep 1;11(1):17479. doi: 10.1038/s41598-021-96748-z.
3
A Current and Newly Proposed Artificial Intelligence Algorithm for Reading Small Bowel Capsule Endoscopy.
一种用于解读小肠胶囊内镜的当前及新提出的人工智能算法。
Diagnostics (Basel). 2021 Jun 29;11(7):1183. doi: 10.3390/diagnostics11071183.
4
Deep learning for wireless capsule endoscopy: a systematic review and meta-analysis.深度学习在无线胶囊内窥镜中的应用:系统评价和荟萃分析。
Gastrointest Endosc. 2020 Oct;92(4):831-839.e8. doi: 10.1016/j.gie.2020.04.039. Epub 2020 Apr 22.
5
CAD-CAP: a 25,000-image database serving the development of artificial intelligence for capsule endoscopy.CAD-CAP:一个拥有25000张图像的数据库,用于支持胶囊内镜人工智能的开发。
Endosc Int Open. 2020 Mar;8(3):E415-E420. doi: 10.1055/a-1035-9088. Epub 2020 Feb 21.
6
Automatic detection of blood content in capsule endoscopy images based on a deep convolutional neural network.基于深度卷积神经网络的胶囊内镜图像中血液内容的自动检测。
J Gastroenterol Hepatol. 2020 Jul;35(7):1196-1200. doi: 10.1111/jgh.14941. Epub 2019 Dec 27.
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Deep learning algorithms for automated detection of Crohn's disease ulcers by video capsule endoscopy.基于视频胶囊内镜的深度学习算法自动检测克罗恩病溃疡
Gastrointest Endosc. 2020 Mar;91(3):606-613.e2. doi: 10.1016/j.gie.2019.11.012. Epub 2019 Nov 16.
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Gastroenterologist-Level Identification of Small-Bowel Diseases and Normal Variants by Capsule Endoscopy Using a Deep-Learning Model.胶囊内镜使用深度学习模型对小肠疾病和正常变异进行胃肠病学家级别的识别。
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