School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China.
Engineering Research Center of Health Food Design & Nutrition Regulation, Dongguan Key Laboratory of Typical Food Precision Design, China National Light Industry Key Laboratory of Healthy Food Development and Nutrition Regulation, School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Nutrients. 2023 Sep 29;15(19):4206. doi: 10.3390/nu15194206.
Excessive exercise without adequate rest can lead to overtraining syndrome, which manifests a series of side effects, including fatigue, gut dysbiosis, and decremental sports performance. Konjac glucomannan (KGM) is a plant polysaccharide with numerous health-improving effects, but few studies reported its effects on the gut microbiome, endurance, and strength in an overtraining model. This study assessed the effect of KGM on gut microbiome, endurance, and strength in mice with excessive exercise. Three doses of KGM (1.25, 2.50, and 5.00 mg/mL) were administrated in drinking water to mice during 42 days of a treadmill overtraining program. The results showed that excessive exercise induced a significant microbial shift compared with the control group, while a high dose (5.00 mg/mL) of KGM maintained the microbial composition. The proportion of in feces was significantly increased in the excessive exercise group, while the moderate dose (2.50 mg/mL) of KGM dramatically increased the relative abundance of and SCFA production in feces. Additionally, the moderate dose and high dose of KGM counteracted the negative effects of excessive exercise on strength or/and endurance (43.14% and 39.94% increase through a moderate dose of KGM, Bonferroni corrected < 0.05, compared with the excessive exercise group). Therefore, it suggests that KGM could prevent overtraining and improve sports performance in animal models.
过度运动而没有充足的休息会导致过度训练综合征，其表现出一系列副作用，包括疲劳、肠道菌群失调和运动表现下降。葡甘露聚糖（KGM）是一种具有多种健康益处的植物多糖，但很少有研究报道其在过度训练模型中对肠道微生物组、耐力和力量的影响。本研究评估了 KGM 对过度运动小鼠肠道微生物组、耐力和力量的影响。在为期 42 天的跑步机过度训练计划中，将三种剂量的 KGM（1.25、2.50 和 5.00mg/mL）添加到饮用水中给小鼠。结果表明，与对照组相比，过度运动诱导了显著的微生物变化，而高剂量（5.00mg/mL）的 KGM 维持了微生物组成。粪便中 的比例在过度运动组中显著增加，而中剂量（2.50mg/mL）的 KGM 则显著增加了粪便中 和 SCFA 的相对丰度。此外，中剂量和高剂量的 KGM 抵消了过度运动对力量或/和耐力的负面影响（通过中剂量的 KGM 增加了 43.14%和 39.94%，Bonferroni 校正 < 0.05，与过度运动组相比）。因此，这表明 KGM 可以预防动物模型中的过度训练并提高运动表现。
