Karlsson-Good Magnus, Kaldo Viktor, Lundberg Linnea, Kraepelien Martin, Anthony Susanne A, Holländare Fredrik
Department of Psychiatry, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Internet Interv. 2023 Oct 4;34:100678. doi: 10.1016/j.invent.2023.100678. eCollection 2023 Dec.
Research shows that internet-based cognitive behavioural therapy (iCBT) is an effective treatment for depression. However, little is known about how the length of the text material in iCBT affects outcomes.
The aim of this study was to test whether a condensed iCBT version for depression would be non-inferior to the existing full-text version in reducing depressive symptoms at post-treatment. We also wanted to test non-inferiority for secondary outcomes and explore reading speed and ADHD symptoms as potential moderators.
A single-blind randomized controlled trial was conducted (N = 267) comparing two versions of guided iCBT for depression; full-text (around 60,000 words) and condensed (around 30,000 words, with the option to listen to the text). Estimated between-group effect sizes and their confidence intervals for depression, anxiety and quality of life, were compared to a pre-determined non-inferiority margin (ES = 0.4). Moderation analyses of reading speed and ADHD symptoms were conducted.
The condensed version of iCBT was non-inferior to the full-text version on post-treatment measures for depressive symptoms (95 % CI = -0.42-0.24), anxiety symptoms (95 % CI = -0.24-0.32), and quality of life (95 % CI = -0.09-0.49). Non-inferiority was inconclusive for depressive symptoms at the one-year follow-up (95 % CI = -0.60-0.47). There was no significant moderation effects of reading speed (p = 0.06) or ADHD symptoms (p = 0.11) on depressive symptoms.
These results indicate that a condensed version of iCBT for depression is as effective at treating depression as the full-text version. By shortening texts, iCBT may be made available to more people. Due to unequal dropout rates between the groups, these results are preliminary and need to be replicated.
研究表明,基于互联网的认知行为疗法(iCBT)是治疗抑郁症的有效方法。然而,对于iCBT中文本材料的长度如何影响治疗效果,人们知之甚少。
本研究的目的是测试抑郁症的浓缩版iCBT在治疗后减轻抑郁症状方面是否不劣于现有的全文版。我们还想测试次要结果的非劣效性,并探索阅读速度和注意力缺陷多动障碍(ADHD)症状作为潜在的调节因素。
进行了一项单盲随机对照试验(N = 267),比较两种抑郁症指导性iCBT版本;全文版(约60,000字)和浓缩版(约30,000字,可选择听文本)。将抑郁症、焦虑症和生活质量的组间效应量估计值及其置信区间与预先确定的非劣效性界值(ES = 0.4)进行比较。对阅读速度和ADHD症状进行调节分析。
iCBT的浓缩版在抑郁症状(95% CI = -0.42 - 0.24)、焦虑症状(95% CI = -0.24 - 0.32)和生活质量(95% CI = -0.09 - 0.49)的治疗后测量中不劣于全文版。在一年随访时,抑郁症状的非劣效性尚无定论(95% CI = -0.60 - 0.47)。阅读速度(p = 0.06)或ADHD症状(p = 0.11)对抑郁症状没有显著的调节作用。
这些结果表明,抑郁症的浓缩版iCBT在治疗抑郁症方面与全文版一样有效。通过缩短文本,iCBT可能会让更多人能够使用。由于两组间的失访率不相等,这些结果是初步的,需要重复验证。