一种用于筛选XNA单体对DNA和RNA代谢干扰作用的微生物系统。
A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism.
作者信息
Blanchard Aude, Abramov Mikhail, Hassan Camille, Marlière Philippe, Herdewijn Piet, Pezo Valérie
机构信息
Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay 2 Rue Gaston Crémieux 91057 Evry France
Laboratory for Medicinal Chemistry, Rega Institute Herestraat 49, KU Leuven Leuven Belgium.
出版信息
RSC Adv. 2023 Oct 12;13(43):29862-29865. doi: 10.1039/d3ra06172h. eCollection 2023 Oct 11.
We explored the toxicity and mutagenicity of a wide range of xenobiotic nucleoside triphosphates to an strain equipped with a nucleoside triphosphate transporter. This bacterial test provides a tool to evaluate and guide the synthesis of nucleotides for applications such as the propagation of non-natural genetic information or the selection of potential drugs.
我们研究了多种外源核苷三磷酸对配备核苷三磷酸转运蛋白的菌株的毒性和诱变性。这种细菌测试提供了一种工具，可用于评估和指导核苷酸的合成，以用于非天然遗传信息的传递或潜在药物的筛选等应用。
Zotero 插件