Sharda Deepinder, Kaur Pawandeep, Choudhury Diptiman
School of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala, Punjab, 147004, India.
Thapar Institute of Engineering and Technology-Virginia Tech Centre of Excellence for Emerging Materials, Thapar Institute of Engineering and Technology, Patiala, Punjab, 147004, India.
Discov Nano. 2023 Oct 16;18(1):127. doi: 10.1186/s11671-023-03903-8.
Prolonged inflammation can impede wound healing, which is regulated by several proteins and cytokines, including IL-4, IL-10, IL-13, and TGF-β. Concentration-dependent effects of these molecules at the target site have been investigated by researchers to develop them as wound-healing agents by regulating signaling strength. Nanotechnology has provided a promising approach to achieve tissue-targeted delivery and increased effective concentration by developing protein-functionalized nanoparticles with growth factors (EGF, IGF, FGF, PDGF, TGF-β, TNF-α, and VEGF), antidiabetic wound-healing agents (insulin), and extracellular proteins (keratin, heparin, and silk fibroin). These molecules play critical roles in promoting cell proliferation, migration, ECM production, angiogenesis, and inflammation regulation. Therefore, protein-functionalized nanoparticles have emerged as a potential strategy for improving wound healing in delayed or impaired healing cases. This review summarizes the preparation and applications of these nanoparticles for normal or diabetic wound healing and highlights their potential to enhance wound healing.
长期炎症会阻碍伤口愈合，伤口愈合受多种蛋白质和细胞因子调控，包括白细胞介素-4、白细胞介素-10、白细胞介素-13和转化生长因子-β。研究人员已对这些分子在靶位点的浓度依赖性效应进行了研究，以通过调节信号强度将它们开发为伤口愈合剂。纳米技术提供了一种很有前景的方法，通过开发具有生长因子（表皮生长因子、胰岛素样生长因子、成纤维细胞生长因子、血小板衍生生长因子、转化生长因子-β、肿瘤坏死因子-α和血管内皮生长因子）、抗糖尿病伤口愈合剂（胰岛素）和细胞外蛋白（角蛋白、肝素和丝素蛋白）的蛋白质功能化纳米颗粒，实现组织靶向递送并提高有效浓度。这些分子在促进细胞增殖、迁移、细胞外基质产生、血管生成和炎症调节中起关键作用。因此，蛋白质功能化纳米颗粒已成为改善延迟愈合或愈合受损病例伤口愈合的一种潜在策略。本综述总结了这些纳米颗粒在正常或糖尿病伤口愈合中的制备和应用，并强调了它们增强伤口愈合的潜力。
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