Cai Wufeng, Li Jian, Li Qi
Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan Chengdu, 610041, P. R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023 Oct 15;37(10):1292-1299. doi: 10.7507/1002-1892.202306088.
To review the bioactive strategies that enhance tendon graft healing after anterior cruciate ligament reconstruction (ACLR), and to provide insights for improving the therapeutic outcomes of ACLR.
The domestic and foreign literature related to the bioactive strategies for promoting the healing of tendon grafts after ACLR was extensively reviewed and summarized.
At present, there are several kinds of bioactive materials related to tendon graft healing after ACLR: growth factors, cells, biodegradable implants/tissue derivatives. By constructing a complex interface simulating the matrix, environment, and regulatory factors required for the growth of native anterior cruciate ligament (ACL), the growth of transplanted tendons is regulated at different levels, thus promoting the healing of tendon grafts. Although the effectiveness of ACLR has been significantly improved in most studies, most of them are still limited to the early stage of animal experiments, and there is still a long way to go from the real clinical promotion. In addition, limited by the current preparation technology, the bionics of the interface still stays at the micron and millimeter level, and tends to be morphological bionics, and the research on the signal mechanism pathway is still insufficient.
With the further study of ACL anatomy, development, and the improvement of preparation technology, the research of bioactive strategies to promote the healing of tendon grafts after ACLR is expected to be further promoted.
综述前交叉韧带重建（ACLR）术后促进肌腱移植物愈合的生物活性策略，为改善ACLR的治疗效果提供见解。
广泛回顾和总结国内外有关ACLR术后促进肌腱移植物愈合的生物活性策略的文献。
目前，与ACLR术后肌腱移植物愈合相关的生物活性材料有几种：生长因子、细胞、可生物降解植入物/组织衍生物。通过构建模拟天然前交叉韧带（ACL）生长所需的基质、环境和调节因子的复杂界面，在不同水平调节移植肌腱的生长，从而促进肌腱移植物的愈合。尽管在大多数研究中ACLR的有效性已得到显著提高，但大多数仍局限于动物实验的早期阶段，距离真正的临床推广仍有很长的路要走。此外，受当前制备技术的限制，界面的仿生仍停留在微米和毫米水平，且倾向于形态仿生，对信号机制途径的研究仍不充分。
随着对ACL解剖、发育研究的进一步深入以及制备技术的改进，ACLR术后促进肌腱移植物愈合的生物活性策略的研究有望得到进一步推动。
