大鼠胸腺瘤中的前病毒整合位点Mis-1与小鼠浆细胞瘤中的pvt-1易位断点相对应。
Proviral integration site Mis-1 in rat thymomas corresponds to the pvt-1 translocation breakpoint in murine plasmacytomas.
作者信息
Villeneuve L, Rassart E, Jolicoeur P, Graham M, Adams J M
出版信息
Mol Cell Biol. 1986 May;6(5):1834-7. doi: 10.1128/mcb.6.5.1834-1837.1986.
Abstract
Two loci independently implicated in T-and B-lymphocyte neoplasia are shown to be equivalent. The Mis-1 locus is a common proviral integration site in retrovirally induced rat T lymphomas, while the pvt-1 locus on murine chromosome 15 frequently translocates to the kappa locus in plasmacytomas bearing 6;15 translocations. By comparing cloned sequences, we show that pvt-1 is the murine homolog of Mis-1.
摘要
两个分别与T和B淋巴细胞肿瘤形成独立相关的基因座被证明是等同的。Mis-1基因座是逆转录病毒诱导的大鼠T淋巴瘤中常见的前病毒整合位点，而小鼠15号染色体上的pvt-1基因座在携带6;15易位的浆细胞瘤中经常易位至κ基因座。通过比较克隆序列，我们表明pvt-1是Mis-1的小鼠同源物。
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