贫血会导致促红细胞生成素信使核糖核酸在肾脏和肝脏中积累。
Anemia induces accumulation of erythropoietin mRNA in the kidney and liver.
作者信息
Bondurant M C, Koury M J
出版信息
Mol Cell Biol. 1986 Jul;6(7):2731-3. doi: 10.1128/mcb.6.7.2731-2733.1986.
Abstract
Regulation of the production of erythropoietin occurs in the kidney and liver largely through control of accumulation of erythropoietin mRNA. Erythropoietin mRNA was first detected in kidneys at 1.5 h postanemia and reached a plateau value at least 200-fold above the control value by 4 to 8 h. A 20-base sequence immediately upstream from the reported erythropoietin mRNA initiation site is complementary to a hypervariable sequence in 18S rRNA.
摘要
促红细胞生成素的产生调节主要在肾脏和肝脏中通过控制促红细胞生成素mRNA的积累来实现。促红细胞生成素mRNA在贫血后1.5小时首次在肾脏中被检测到，并在4至8小时达到比对照值高至少200倍的稳定值。在报道的促红细胞生成素mRNA起始位点上游紧邻的一个20碱基序列与18S rRNA中的一个高变序列互补。
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