Anagnostou A, Schade S, Barone J, Fried W
Blood. 1977 Sep;50(3):457-62.
Studies were performed to determine the effects of partial hepatectomy on extra-renal erythropoietin production. Rats were either partially hepatectomized or sham operated. At intervals of from 5 min to 7 days afterward, both kidneys were removed from cohorts of the above two groups of rats and the animals were then exposed to hypoxia for 7.5 hr. Immediately afterward, their plasma was collected and its erythropoietin titer was assayed. Rats which were partially hepatectomized 2-4 days prior to nephrectomy and hypoxia had significantly higher plasma erythropoietin levels than did sham-operated controls, whereas rats hepatectomized 5 min, 1 day, or 7 days prior to nephrectomy and hypoxia did not. These data are consistent with the conclusion that extrarenal erythropoietin production is enhanced in association with rapid regeneration of hepatic cells.
进行了多项研究以确定部分肝切除术对肾外促红细胞生成素产生的影响。将大鼠分为部分肝切除组或假手术组。在术后5分钟至7天的不同时间间隔，从上述两组大鼠中各选取一组，摘除其双侧肾脏，然后使动物暴露于低氧环境7.5小时。随后立即采集其血浆并测定促红细胞生成素滴度。在肾切除及低氧处理前2 - 4天接受部分肝切除术的大鼠，其血浆促红细胞生成素水平显著高于假手术对照组，而在肾切除及低氧处理前5分钟、1天或7天接受肝切除术的大鼠则不然。这些数据支持以下结论：肾外促红细胞生成素的产生与肝细胞的快速再生相关，且会增强。
