Wang Chenmin, Hu Chengwei, Cheng Haojin, Qi Weichen, Wang Liangliang, Wu Tianchi, Wu Jun, Cui Xu, Xu Jiake, Pan Haobo, Bian Shaoquan, Lu Weijia William, Zhao Xiaoli
Research Center for Human Tissue and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, 999077, China.
Adv Sci (Weinh). 2024 Dec;11(46):e2405823. doi: 10.1002/advs.202405823. Epub 2024 Oct 22.
Bioprinting technology plays a crucial role for constructing tissue substitutes. However, the mismatched scaffold shapes and the poor treatment timeliness limit its clinical translational application. In situ printing technology that prints bioregenerants directly inside patient's body can meet the needs of specific tissue repair. This study develops a smartphone controlled handheld bioprinter for in situ skin wounds dressing. The mini bioprinter can be handheld and placed on any printing surface to create strips, complex patterns, and 3D structures, and can be equipped with microchannel needles to expand functionality. The size of the strips as well as the printing path can be programmed and controlled by the smartphone to ensure the precision of the printed product quality. Furthermore, the device not only allows for smooth switching between different bioinks for printing heterogeneous structure, but also allows for fast and uniform coverage of large wound surfaces. When dealing with complex wounds in vitro & vivo, the printer can effectively fill and precisely close wounds, promoting wound healing. The programmable handheld bioprinter can balance mobility and customizability in the management of skin wounds and is expected to realize its potential for emergency medical treatment in condition-constrained scenarios, such as battlefields or disaster areas.
生物打印技术在构建组织替代物方面发挥着关键作用。然而，支架形状不匹配和治疗及时性差限制了其临床转化应用。直接在患者体内打印生物再生剂的原位打印技术可以满足特定组织修复的需求。本研究开发了一种用于原位皮肤伤口敷料的智能手机控制的手持式生物打印机。这种微型生物打印机可以手持并放置在任何打印表面上，以创建条带、复杂图案和三维结构，并且可以配备微通道针以扩展功能。条带的尺寸以及打印路径可以通过智能手机进行编程和控制，以确保打印产品质量的精度。此外，该设备不仅允许在不同生物墨水之间平稳切换以打印异质结构，还允许快速且均匀地覆盖大的伤口表面。在体外和体内处理复杂伤口时，该打印机可以有效地填充并精确闭合伤口，促进伤口愈合。这种可编程手持式生物打印机在皮肤伤口管理中可以平衡移动性和定制性，并有望在战场或灾区等条件受限的场景中实现其在紧急医疗治疗中的潜力。
