Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases, Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Sichuan, China.
Breast Cancer Res. 2023 Oct 19;25(1):126. doi: 10.1186/s13058-023-01728-y.
Breast cancer metastasis is a complex, multi-step process, with high cellular heterogeneity between primary and metastatic breast cancer, and more complex interactions between metastatic cancer cells and other cells in the tumor microenvironment. High-resolution single-cell transcriptome sequencing technology can visualize the heterogeneity of malignant and non-malignant cells in the tumor microenvironment in real time, especially combined with spatial transcriptome analysis, which can directly compare changes between different stages of metastatic samples. Therefore, this study takes single-cell analysis as the first perspective to deeply explore special or rare cell subpopulations related to breast cancer metastasis, systematically summarizes their functions, molecular features, and corresponding treatment strategies, which will contribute to accurately identify, understand, and target tumor metastasis-related driving events, provide a research basis for the mechanistic study of breast cancer metastasis, and provide new clues for its personalized precision treatment.
乳腺癌转移是一个复杂的、多步骤的过程，原发和转移性乳腺癌之间具有高度的细胞异质性，转移性癌细胞与肿瘤微环境中的其他细胞之间的相互作用也更加复杂。高分辨率单细胞转录组测序技术可以实时可视化肿瘤微环境中恶性和非恶性细胞的异质性，特别是与空间转录组分析相结合，可以直接比较转移样本不同阶段之间的变化。因此，本研究以单细胞分析为第一视角，深入探索与乳腺癌转移相关的特殊或罕见细胞亚群，系统总结其功能、分子特征和相应的治疗策略，这将有助于准确识别、理解和靶向肿瘤转移相关的驱动事件，为乳腺癌转移的机制研究提供依据，并为其个体化精准治疗提供新线索。
