Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, NIA/NIH/IRP, Baltimore, Maryland, USA.
U.S. Department of Veterans Affairs, VA National Center on Homelessness Among Veterans, Washington, District of Columbia, USA.
Alzheimers Dement. 2024 Sep;20(9):6468-6485. doi: 10.1002/alz.14141. Epub 2024 Aug 8.
Relationships and interplay of an infection burden (IB) and periodontal pathogens or periodontal disease (Pd) markers with Alzheimer's disease (AD) and all-cause dementia among US adults were examined.
Less than or equal to 2997 participants from the National Health and Nutrition Survey III were linked to CMS-Medicare [≥45 years (1988-1994); ≤30 years follow-up].
Hepatitis C (hazard ratio = 3.33, p = 0.004) and herpes simplex virus 2 were strongly associated with greater all-cause dementia risk. Porphyromonas gingivalis and Streptococcus oralis were associated with greater AD risk at higher IB. The red-green periodontal pathogen cluster coupled with higher IB count increased the risk of all-cause dementia among minority racial groups. Pocket probing depth associated with dementia risk at lower IB in the overall sample.
Select viruses and bacteria were associated with all-cause and AD dementia, while the IB interacted with Pd markers in relation to these outcomes.
Interplay of infection burden (IB) and periodontal disease with dementia was tested. ≤2997 participants from NHANES III were linked to Medicare. Hepatitis C and herpes simplex virus 2 strongly associated with dementia risk. Tetanus sero-positivity increased Alzheimer's disease (AD) risk. Porphyromonas gingivalis and Streptococcus oralis associated with AD at higher IB. Red-green periodontal cluster at high IB, increased dementia in racial minorities. Pocket probing depth associated with dementia risk at lower IB.
本研究旨在探讨美国成年人的感染负担（IB）和牙周病病原体或疾病标志物与阿尔茨海默病（AD）和全因痴呆之间的关系和相互作用。
我们将国家健康和营养调查 III 中年龄小于或等于 2997 名参与者与 CMS-Medicare（年龄大于或等于 45 岁（1988-1994 年）；随访时间小于或等于 30 年）进行关联。
丙型肝炎（危险比=3.33，p=0.004）和单纯疱疹病毒 2 与全因痴呆风险增加密切相关。牙龈卟啉单胞菌和口腔链球菌与较高的 IB 下的 AD 风险增加相关。较高的 IB 计数与较高的牙周病病原体红色-绿色聚类相关，增加了少数族裔人群全因痴呆的风险。在整个样本中，较低的 IB 与痴呆风险相关的探诊深度。
一些特定的病毒和细菌与全因痴呆和 AD 痴呆相关，而 IB 与 Pd 标志物相互作用与这些结果有关。
本研究测试了感染负担（IB）和牙周病与痴呆之间的相互作用。NHANES III 的≤2997 名参与者与 Medicare 相关联。丙型肝炎和单纯疱疹病毒 2 与痴呆风险密切相关。破伤风血清阳性增加阿尔茨海默病（AD）风险。牙龈卟啉单胞菌和口腔链球菌与较高的 IB 相关的 AD。高 IB 下的红色-绿色牙周病聚类增加了少数族裔的痴呆风险。低 IB 下的探诊深度与痴呆风险相关。
