Colvett Isaac, Saternos Hannah, Coughlan Christina, Vielle Anne, Ledreux Aurélie
Department of Neurosurgery, School of Medicine, University of Colorado Anschutz Medical Campus,12700 E 19th Ave Aurora, CO 80045, United States.
Department of Neurology, School of Medicine, University of Colorado Anschutz Medical Campus,12700 E 19th Ave Aurora, CO 80045, United States.
Extracell Vesicles Circ Nucl Acids. 2023 Mar;4(1):72-89. doi: 10.20517/evcna.2023.07. Epub 2023 Mar 29.
Intercellular communication between diverse cell types is crucial for the maintenance of the central nervous system, and exosomes have been shown to play an important role in this process. Exosomes are small extracellular vesicles (EVs) that are released by all cell types and carry cargoes that can elicit downstream effects in recipient cells. Exosomal communication in the central nervous system has been implicated in many neurodegenerative diseases, ranging from Alzheimer's disease to major depressive disorder. Though there remain many unknowns in the field of EV biology, experiments can provide many insights into their potential roles in health and disease. In this review, we discuss the findings of many EV experiments, with a focus on the potential roles in regulating cell viability, inflammation, oxidative stress, and neurite integrity in the central nervous system.
不同细胞类型之间的细胞间通讯对于中枢神经系统的维持至关重要，并且外泌体已被证明在这一过程中发挥重要作用。外泌体是由所有细胞类型释放的小细胞外囊泡（EVs），携带的物质可在受体细胞中引发下游效应。中枢神经系统中的外泌体通讯与许多神经退行性疾病有关，从阿尔茨海默病到重度抑郁症。尽管在细胞外囊泡生物学领域仍有许多未知之处，但实验可以为它们在健康和疾病中的潜在作用提供许多见解。在这篇综述中，我们讨论了许多细胞外囊泡实验的结果，重点关注其在调节中枢神经系统细胞活力、炎症、氧化应激和神经突完整性方面的潜在作用。
