Akbari-Gharalari Naeimeh, Khodakarimi Sina, Nezhadshahmohammad Farshad, Karimipour Mohammad, Ebrahimi-Kalan Abbas, Wu Jiagian
Department of Neurosciences and Cognition, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Mining Engineering, Faculty of Engineering, Urmia University, Urmia, Iran.
Bioimpacts. 2024;14(5):30153. doi: 10.34172/bi.2023.30153. Epub 2024 Jan 7.
Exosomes, a subset of extracellular vesicles (EVs), are crucial for intercellular communication in various contexts. Despite their small size, they carry diverse cargo, including RNA, proteins, and lipids. Internalization by recipient cells raises concerns about potential disruptions to cellular functions. Notably, the ability of exosomes to traverse the blood-brain barrier (BBB) has significant implications.
To conduct a thorough investigation into the existing academic literature on exosomes within the framework of neuron-glia communication, a comprehensive search strategy was implemented across the PubMed, Google Scholar, and Science Direct databases. Multiple iterations of the keywords "exosome," "neuron-glia communication," and "neurological disorders" were employed to systematically identify relevant publications. Furthermore, an exploration of the Clinicaltrials.gov database was undertaken to identify clinical trials related to cellular signaling, utilizing analogous terminology.
Although the immediate practical applications of exosomes are somewhat limited, their potential as carriers of pathogenic attributes offers promising opportunities for the development of precisely targeted therapeutic strategies for neurological disorders. This review presents a comprehensive overview of contemporary insights into the pivotal roles played by exosomes as agents mediating communication between neurons and glial cells within the central nervous system (CNS).
By delving into the intricate dynamics of exosomal communication in the CNS, this review contributes to a deeper understanding of the roles of exosomes in both physiological and pathological processes, thereby paving the way for potential therapeutic advancements in the field of neurological disorders.
外泌体是细胞外囊泡（EVs）的一个子集，在各种情况下对细胞间通讯至关重要。尽管它们体积小，但携带多种物质，包括RNA、蛋白质和脂质。受体细胞的内化引发了对细胞功能潜在干扰的担忧。值得注意的是，外泌体穿越血脑屏障（BBB）的能力具有重要意义。
为了在神经元-胶质细胞通讯框架内对现有的关于外泌体的学术文献进行全面调查，在PubMed、谷歌学术和科学Direct数据库中实施了全面的搜索策略。多次使用关键词“外泌体”、“神经元-胶质细胞通讯”和“神经疾病”来系统地识别相关出版物。此外，还对Clinicaltrials.gov数据库进行了探索，以利用类似术语识别与细胞信号传导相关的临床试验。
尽管外泌体的直接实际应用有些有限，但其作为致病属性载体的潜力为开发针对神经疾病的精确靶向治疗策略提供了有希望的机会。本综述全面概述了当代对外泌体作为介导中枢神经系统（CNS）中神经元和胶质细胞之间通讯的介质所起关键作用的见解。
通过深入研究中枢神经系统中外泌体通讯的复杂动态，本综述有助于更深入地理解外泌体在生理和病理过程中的作用，从而为神经疾病领域的潜在治疗进展铺平道路。
