Grundmann R
Fortschr Med. 1979 Oct 11;97(38):1668-74.
The efficiency of hypothermic mechanical perfusion and hypothermic storage, resp., for kidney preservation was to be examined. For this purpose dog kidneys were subdued to 0 to 60 min of warm ischemia, then preserved for 12--72 hours and thereafter transplanted. It could be concluded: 1. Hypothermic mechanical perfusion makes a successful 72 hour preservation possible with excellent kidney function immediately after transplantation. After 30 minutes of warm ischemia the preservation period should be limited to 24 hours. 2. Hypothermic storage is inferior to mechanical perfusion concerning the immediate function after transplantation: 24 hours storage time and 15 minutes of warm ischemia should not be exceeded. 3. Kidney function decreases exponentially by the time of preservation. This means that the warm ischemic period and the preservation time, resp., should be as short as possible to get an undamaged kidney after transplantation: the shorter the preservation period the better the kidney function after transplantation.
分别对低温机械灌注和低温保存用于肾脏保存的效率进行了研究。为此,将犬肾进行0至60分钟的热缺血处理,然后保存12至72小时,之后进行移植。可以得出以下结论:1. 低温机械灌注能够成功实现72小时的保存,移植后肾功能立即良好。热缺血30分钟后,保存期应限制在24小时以内。2. 就移植后的即时功能而言,低温保存不如机械灌注:储存时间不应超过24小时,热缺血时间不应超过15分钟。3. 肾功能随保存时间呈指数下降。这意味着热缺血期和保存时间应尽可能短,以便移植后获得未受损的肾脏:保存期越短,移植后肾功能越好。