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[机械灌注与低温保存肾脏的比较研究]

[Kidney preservation by mechanical perfusion and by hypothermic storage: a comparative study].

作者信息

Grundmann R, Eichmann J, Strümper R, Pichlmaier H

出版信息

Chir Forum Exp Klin Forsch. 1977 Apr:235-9.

PMID:618309
Abstract

72 dog kidneys were stored under hypothermia as described by COLLINS and SACKS between 24 and 72 hrs and then transplanted. The immediate function of the kidneys was measured by PAH and inulin clearances. 24 hrs proved to be the maximum safe preservation time with both methods. The immediate function of the kidneys stored under hypothermia could not be improved by the addition of furosemide to the flushing solution. These results were compared with those gained by mechanical perfusion of the organ: kidney function after 72 hrs of hypothermic mechanical perfusion was significantly better than after 24 hrs of hypothermic storage.

摘要

72个犬肾按照柯林斯和萨克斯所描述的方法在低温下保存24至72小时,然后进行移植。通过对氨基马尿酸(PAH)清除率和菊粉清除率来测定肾脏的即时功能。两种方法均表明24小时是最大安全保存时间。在冲洗液中添加呋塞米并不能改善低温保存下肾脏的即时功能。这些结果与通过器官机械灌注获得的结果进行了比较:低温机械灌注72小时后的肾功能明显优于低温保存24小时后的肾功能。

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