Brisset Morgan, Mehlen Patrick, Meurette Olivier, Hollande Frédéric
Department of Clinical Pathology, Victorian Comprehensive Cancer Centre, The University of Melbourne, Melbourne, VIC, Australia.
Centre for Cancer Research, The University of Melbourne, Melbourne, VIC, Australia.
Front Cell Dev Biol. 2023 Oct 4;11:1231416. doi: 10.3389/fcell.2023.1231416. eCollection 2023.
Cancer cell heterogeneity is a key contributor to therapeutic failure and post-treatment recurrence. Targeting cell subpopulations responsible for chemoresistance and recurrence seems to be an attractive approach to improve treatment outcome in cancer patients. However, this remains challenging due to the complexity and incomplete characterization of tumor cell subpopulations. The heterogeneity of cells exhibiting stemness-related features, such as self-renewal and chemoresistance, fuels this complexity. Notch signaling is a known regulator of cancer stem cell (CSC) features in colorectal cancer (CRC), though the effects of its heterogenous signaling on CRC cell stemness are only just emerging. In this review, we discuss how Notch ligand-receptor specificity contributes to regulating stemness, self-renewal, chemoresistance and cancer stem cells heterogeneity in CRC.
癌细胞异质性是导致治疗失败和治疗后复发的关键因素。靶向负责化疗耐药性和复发的细胞亚群似乎是改善癌症患者治疗效果的一种有吸引力的方法。然而，由于肿瘤细胞亚群的复杂性和特征描述不完整，这仍然具有挑战性。表现出与干性相关特征（如自我更新和化疗耐药性）的细胞的异质性加剧了这种复杂性。Notch信号通路是已知的结直肠癌（CRC）中癌症干细胞（CSC）特征的调节因子，尽管其异质信号对CRC细胞干性的影响才刚刚显现。在这篇综述中，我们讨论了Notch配体-受体特异性如何有助于调节CRC中的干性、自我更新、化疗耐药性和癌症干细胞异质性。
