Mattila M A, Säilä K, Kokko T, Kärkkäinen T
Br J Anaesth. 1979 Apr;51(4):329-37. doi: 10.1093/bja/51.4.329.
A comparison has been made between the effects of the administration of flunitrazepam 1 mg i.v. and diazepam 10 mg i.v. in 90 female patients undergoing abdominal surgery. The drugs were given immediately before the skin incision as a booster to the induction agent thiopentone. The response to the incision, the quality of anaesthesia and the need for supplementary medication during maintenance were monitored. A standard post-anaesthesia interview was performed to evaluate the amnesic action and patient acceptability. The skin incision caused only slight increase in arterial pressure and heart rate in both groups. Only six patients of the diazepam group reacted to the incision with defensive movements. The overall quality of anaesthesia was better (P less than 0.05) and the need for supplementary doses of pethidine lower (P less than 0.01) in the flunitrazepam group. Recovery was equally good and the duration of sleep after operation was the same in both groups. The frequency of nausea after operation was low. The post-anaesthesia interview revealed that flunitrazepam possesses a more specific anterograde amnesic action than diazepam. Acceptability of the anaesthesia to the patient was equally good in both groups.
对90例接受腹部手术的女性患者静脉注射1毫克氟硝西泮和静脉注射10毫克地西泮的效果进行了比较。这些药物在皮肤切口前立即给药，作为诱导剂硫喷妥钠的增强剂。监测对切口的反应、麻醉质量以及维持期间补充用药的需求。进行了标准的麻醉后访谈，以评估遗忘作用和患者的可接受性。两组患者的皮肤切口仅引起动脉压和心率轻微升高。地西泮组只有6例患者对切口有防御性动作反应。氟硝西泮组的总体麻醉质量更好（P<0.05），哌替啶补充剂量的需求更低（P<0.01）。两组的恢复情况同样良好，术后睡眠时间相同。术后恶心的发生率较低。麻醉后访谈显示，氟硝西泮比地西泮具有更特异的顺行性遗忘作用。两组患者对麻醉的可接受性同样良好。
