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TNFR1、VEGFA、CD147 和 MCT1 的表达作为糖尿病并发症的早期生物标志物，以及衰老对该特征的影响。

Expression of TNFR1, VEGFA, CD147 and MCT1 as early biomarkers of diabetes complications and the impact of aging on this profile.

机构信息

Laboratório de Análises Clínicas do Centro Universitário-Faculdade de Medicina do ABC (FMABC), Avenida Lauro Gomes, 2000, Santo André, SP, 09060-650, Brazil.

Vivarium and Animal Experimentation Laboratory-Faculdade de Medicina Do ABC (FMABC), Avenida Lauro Gomes, 2000, Santo André, SP, 09060-650, Brazil.

出版信息

Sci Rep. 2023 Oct 20;13(1):17927. doi: 10.1038/s41598-023-41061-0.

DOI:10.1038/s41598-023-41061-0
PMID:37863950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10589356/
Abstract

Hyperglycemia leads to microvascular lesions in various tissues. In diabetic nephropathy-DN, alterations in usual markers reflect an already installed disease. The study of new biomarkers for the early detection of diabetic complications can bring new prevention perspectives. Rats were divided into diabetic adult-DMA-or elderly-DME and control sham adult-CSA-or control sham elderly-CSE. Blood and urine samples were collected for biochemical analysis. Bulbar region, cardiac, hepatic and renal tissues were collected for target gene expression studies. As result, DMA showed decreased TNFR1, MCT1 and CD147 expression in the bulbar region, TNFR1 in the heart, VEGFA and CD147 in the kidney and TNFR1 in blood. Positive correlations were found between TNFR1 and MCT1 in the bulbar region and HbA1c and plasma creatinine, respectively. DME showed positive correlation in the bulbar region between TNFR1 and glycemia, in addition to negative correlations between CD147 in the heart versus glycemia and urea. We concluded that the initial hyperglycemic stimulus already promotes changes in the expression of genes involved in the inflammatory and metabolic pathways, and aging alters this profile. These changes prior to the onset of diseases such as DN, show that they have potential for early biomarkers studies.

摘要

高血糖导致各种组织的微血管病变。在糖尿病肾病-DN 中，通常标志物的改变反映了已经存在的疾病。研究新的生物标志物来早期发现糖尿病并发症可以带来新的预防前景。将大鼠分为成年糖尿病-DMA-或老年糖尿病-DME 和对照假手术成年-CSA-或对照假手术老年-CSE。收集血液和尿液样本进行生化分析。收集球部、心脏、肝脏和肾脏组织进行靶基因表达研究。结果显示，DMA 组球部 TNFR1、MCT1 和 CD147 表达降低，心脏 TNFR1 表达降低，肾脏 VEGFA 和 CD147 表达降低，血液 TNFR1 表达降低。TNFR1 在球部与 HbA1c 和血浆肌酐呈正相关，MCT1 也呈正相关。DME 组球部 TNFR1 与血糖呈正相关，心脏 CD147 与血糖和尿素呈负相关。我们得出结论，初始高血糖刺激已经导致参与炎症和代谢途径的基因表达发生变化，而衰老改变了这种模式。这些在 DN 等疾病发生之前的变化表明，它们有可能用于早期生物标志物的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3060/10589356/f7c419c56189/41598_2023_41061_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3060/10589356/daf80c9005cc/41598_2023_41061_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3060/10589356/0eafabeeb283/41598_2023_41061_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3060/10589356/24f311493f28/41598_2023_41061_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3060/10589356/b70f27dfed3c/41598_2023_41061_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3060/10589356/f7c419c56189/41598_2023_41061_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3060/10589356/daf80c9005cc/41598_2023_41061_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3060/10589356/0eafabeeb283/41598_2023_41061_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3060/10589356/24f311493f28/41598_2023_41061_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3060/10589356/b70f27dfed3c/41598_2023_41061_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3060/10589356/f7c419c56189/41598_2023_41061_Fig5_HTML.jpg

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