Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
J Cosmet Dermatol. 2024 Mar;23(3):839-848. doi: 10.1111/jocd.16043. Epub 2023 Oct 21.
Vitiligo is a disease of acquired depigmentation characterized by the destruction of melanocytes. A theoretical association between low level of 25-hydroxyvitamin D [25(OH)D] and vitiligo has been previously suggested. The objective of this study was to determine the efficacy of intramuscular injection of cholecalciferol with excimer laser compared with the excimer laser alone for vitiligo treatment.
This study included 26 patients diagnosed with non-segmental vitiligo and low serum 25(OH)D levels (<20 ng/mL). The participants were randomly divided into two groups through randomization. The treatment using a 308-nm excimer laser was administered to both groups, and the study group additionally received cholecalciferol injection.
The Vitiligo Area Scoring Index (VASI) scores showed an 83.6% improvement over the initial score in the study group, whereas the control group showed a 54.7% improvement after 6 months of treatment. After 6 months of treatment, the study group showed a significantly higher proportion of patients who achieved VASI50 and VASI75 compared with the control group.
Intramuscular injection of cholecalciferol can be a supplemental option for the treatment of vitiligo patients with vitamin D deficiency with excimer laser therapy.
白癜风是一种获得性色素减退疾病，其特征是黑素细胞破坏。先前曾提出 25-羟维生素 D [25(OH)D]水平低与白癜风之间存在理论关联。本研究的目的是确定肌内注射胆钙化醇联合准分子激光与单独使用准分子激光治疗白癜风的疗效。
本研究纳入了 26 名诊断为非节段性白癜风且血清 25(OH)D 水平低（<20ng/mL）的患者。参与者通过随机分组分为两组。两组均接受 308nm 准分子激光治疗，研究组额外接受胆钙化醇注射。
研究组的白癜风面积评分指数（VASI）评分在初始评分的基础上提高了 83.6%，而对照组在治疗 6 个月后提高了 54.7%。治疗 6 个月后，与对照组相比，研究组达到 VASI50 和 VASI75 的患者比例显著更高。
对于维生素 D 缺乏的白癜风患者，肌内注射胆钙化醇可作为使用准分子激光治疗的补充选择。
