Department of Dermatology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China.
Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing, China.
Skin Res Technol. 2024 Aug;30(8):e13911. doi: 10.1111/srt.13911.
The clinical strategy of oral supplementation of Vitamin D (VD) as a preventive and therapeutic measure for warts needs further exploration.
The clinical data of patients with skin diseases who visited the Children's Hospital affiliated with Chongqing Medical University from February 2018 to June 2024 were collected. The serum VD levels in patients with warts (common warts, flat warts, and plantar warts) and patients with other common skin diseases (atopic dermatitis, psoriasis, alopecia areata, vitiligo, and chronic urticaria) were compared. Two-sample bidirectional Mendelian randomization (MR) analysis was performed to investigate potential causal associations between VD and warts.
The average serum VD level of children with warts was 23.27 ± 7.07 ng/mL, which showed no statistically significant difference compared to children with other common skin diseases. The inverse variance weighted (IVW) method analysis indicated a positive causal relationship between VD and warts (Odds Ratio [OR] = 1.86, [95% CI: 1.19-2.92], p = 0.007). Sensitivity analysis did not show any indication of horizontal pleiotropy or heterogeneity. The MR-PRESSO method did not identify any outliers.
The levels of serum VD in children with warts do not significantly decrease compared to children with other common skin conditions. The evidence from the MR analysis indicates a positive causal relationship between VD and warts, suggesting caution in supplementing VD for children with warts who have normal or elevated serum VD levels. Further clinical studies are needed for validation in the future.
口服补充维生素 D（VD）作为预防和治疗疣的临床策略需要进一步探索。
收集 2018 年 2 月至 2024 年 6 月期间重庆医科大学附属儿童医院皮肤科就诊的皮肤病患者的临床资料。比较疣（寻常疣、扁平疣和跖疣）患者和其他常见皮肤病（特应性皮炎、银屑病、斑秃、白癜风和慢性荨麻疹）患者的血清 VD 水平。采用双向 Mendelian 随机化（MR）分析研究 VD 与疣之间的潜在因果关系。
疣患儿的平均血清 VD 水平为 23.27±7.07ng/mL，与其他常见皮肤病患儿相比无统计学差异。逆方差加权（IVW）方法分析表明 VD 与疣之间存在正因果关系（比值比[OR] = 1.86，95%置信区间：1.19-2.92，p = 0.007）。敏感性分析未显示任何水平遗传异质性或平行性的迹象。MR-PRESSO 方法未识别出任何异常值。
与其他常见皮肤病患儿相比，疣患儿的血清 VD 水平无显著降低。MR 分析的证据表明 VD 与疣之间存在正因果关系，提示对于血清 VD 水平正常或升高的疣患儿，补充 VD 应谨慎。未来需要进一步的临床研究进行验证。
