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从茎皮中得到的新prenyl flavanone 和 diarylbutanol 及其 -葡萄糖苷酶抑制活性。

New prenyl flavanone and diarylbutanol from stem bark and their -glucosidase inhibitory activity.

机构信息

Faculty of Chemistry, University of Science, HCM National University, Ho Chi Minh City, Vietnam.

Institute of Environment-Energy Technology, Sai Gon University, Ho Chi Minh City, Vietnam.

出版信息

Nat Prod Res. 2024 Nov;38(22):3982-3988. doi: 10.1080/14786419.2023.2272024. Epub 2023 Oct 22.

Abstract

One new prenyl flavanone (), (2)-8-prenyl-5,6-dihydroxy-7-methoxyflavanone, and one new diarylbutanol (), (7')-3'-hydroxy-linderagatin-A, were isolated from the stem bark of (Annonaceae), along with five known compounds, eriodictyol (), quercetin (), paprazine (), --caffeoyltyramine (), and --feruloyltyramine (). Their structures were determined through extensive spectroscopic analyses and comparison with the literature. The -glucosidase inhibitory potential of was evaluated. Compound showed the highest inhibitory activity against -glucosidase and exhibited superior potency compared to the positive control, with an IC value of 0.12 M.

摘要

从 (番荔枝科)的茎皮中分离得到了一种新的prenyl flavanone(),(2)-8-prenyl-5,6-dihydroxy-7-methoxyflavanone,和一种新的 diarylbutanol(),(7')-3'-hydroxy-linderagatin-A,以及五种已知化合物,eriodictyol(),quercetin(),paprazine(),--caffeoyltyramine(),和--feruloyltyramine()。通过广泛的光谱分析和与文献的比较确定了它们的结构。评估了 的 -葡萄糖苷酶抑制潜力。化合物 对 -葡萄糖苷酶表现出最高的抑制活性,其抑制活性优于阳性对照,IC 值为 0.12 M。

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