Zangade Sainath B, Dhulshette Bashweshawar S, Patil Pravinkumar B
Department of Chemistry, Madhavrao Patil, ACS College, Palam Dist. Parbhani, 431720, (M.S.), India.
Organic Synthesis and Process Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India.
Mini Rev Med Chem. 2024;24(10):1046-1060. doi: 10.2174/0113895575273658231012040250.
Flavonoids and their analogous are mainly found in pink lady apples, green and black tea (catechins), celery and red peppers, onions, broccoli and spinach, berries, cherries, soybean, citrus fruits, and fungi. The different derivatives of flavonoids belonging to polyphenolic compounds such as 3,4',5,7-Tetrahydroxyflavylium (pelargonidin), 2-(3,4-Dihydroxyphenyl)chromenylium-3,5,7-triol (cyanidin), 3,3',4',5,5',7-Hexahydroxyflavylium (delphinidin), 3,3',4',5,7-Pentahydroxy-5'-methoxyflavylium (petunidin), and 3,4',5,7-Tetrahydroxy-3',5'-dimethoxyflavylium (malvidin) can act as good chelating agents for metal-chelate complex formation. These flavonoid-metal complexes have been reported to have various biomedical and pharmacological activities.
Flavonoid-metal ion complexes display a broad spectrum of biological properties such as antioxidant, anti-inflammatory, anti-allergic, antiviral, anticarcinogenic, and cytotoxic activity. The literature survey showed that flavonoid metal complexes have potential therapeutic properties against various cancerous cells. The objective is to gain insight into the current perspective and development of novel anticancer metallodrugs.
The flavonoid-metal ion complexes can be prepared by reacting flavonoid ligand with appropriate metal salt in aqueous or alcoholic reaction medium under stirring or refluxing conditions. In this review article, the various reported methods for the synthesis of flavonoid-metal complexes have been included. The utility of synthetic methods for flavonoid-metal complexes will support the discovery of novel therapeutic drugs.
In this review study, short libraries of flavonoid-metal ion complexes were studied as potential anticancer agents against various human cancer cell lines. The review report reveals that metal ions such as Fe, Co, Ni, Cu, Zn, Rh, Ru, Ga, Ba, Sn etc., when binding to flavonoid ligands, enhance the anticancer activity compared to free ligands. This review study covered some important literature surveys for the last two decades.
It has been concluded that flavonoid metal complexes have been associated with a wide range of biological properties that could be noteworthy in the medicinal field. Therefore, to develop a new anticancer drug, it is essential to determine the primordial interaction of drug with DNA under physiological or anatomical conditions. The study of numerous flavonoid metal complexes mentioned in this paper could be the future treatment against various cancerous diseases.
类黄酮及其类似物主要存在于粉红女士苹果、绿茶和红茶（儿茶素）、芹菜、红辣椒、洋葱、西兰花、菠菜、浆果、樱桃、大豆、柑橘类水果和真菌中。属于多酚类化合物的类黄酮的不同衍生物，如3,4',5,7 - 四羟基黄酮鎓（天竺葵素）、2 - (3,4 - 二羟基苯基)苯并二氢吡喃鎓 - 3,5,7 - 三醇（矢车菊素）、3,3',4',5,5',7 - 六羟基黄酮鎓（飞燕草素）、3,3',4',5,7 - 五羟基 - 5'-甲氧基黄酮鎓（矮牵牛素）和3,4',5,7 - 四羟基 - 3',5'-二甲氧基黄酮鎓（锦葵色素），可作为形成金属螯合物的良好螯合剂。据报道，这些类黄酮 - 金属配合物具有多种生物医学和药理学活性。
类黄酮 - 金属离子配合物具有广泛的生物学特性，如抗氧化、抗炎、抗过敏、抗病毒、抗癌和细胞毒性活性。文献调查表明，类黄酮金属配合物对各种癌细胞具有潜在的治疗特性。目的是深入了解新型抗癌金属药物的当前观点和发展情况。
类黄酮 - 金属离子配合物可通过在搅拌或回流条件下，使类黄酮配体与适当的金属盐在水性或醇性反应介质中反应来制备。在这篇综述文章中，纳入了各种已报道的类黄酮 - 金属配合物的合成方法。类黄酮 - 金属配合物合成方法的实用性将有助于发现新型治疗药物。
在本综述研究中，研究了类黄酮 - 金属离子配合物的短库作为针对各种人类癌细胞系的潜在抗癌剂。综述报告显示，当铁、钴、镍、铜、锌、铑、钌、镓、钡、锡等金属离子与类黄酮配体结合时，与游离配体相比，抗癌活性增强。本综述研究涵盖了过去二十年的一些重要文献调查。
已经得出结论，类黄酮金属配合物具有广泛的生物学特性，在医学领域可能值得关注。因此，要开发一种新的抗癌药物，在生理或解剖条件下确定药物与DNA的原始相互作用至关重要。本文中提到的众多类黄酮金属配合物的研究可能是未来治疗各种癌症疾病的方法。
