Lillis Theodoros, Zisis Vasileios, Fotopoulos Ioannis, Iordanidou Helena, Anagnostou Eleftherios, Andreadis Dimitrios, Poulopoulos Athanasios, Dabarakis Nikolaos
Dentoalveolar Surgery, Implantology and Oral Radiology, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Oral Medicine/Pathology, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Cureus. 2023 Sep 21;15(9):e45669. doi: 10.7759/cureus.45669. eCollection 2023 Sep.
The myxofibroma (MF) constitutes an uncommon, non-malignant, odontogenic neoplasm with potential mesenchymal derivation. The occurrence rate of this particular tumor is estimated to be around 0.05 new cases per million individuals annually. MFs exhibit a higher incidence rate within the age range of 10 to 30 years. The prevalence of these tumors is higher among the female population, with a predominant localization in the mandible, specifically in the posterior region. A female patient, 66 years old, was referred to the Department of Oral Surgery, Surgical Implantology and Radiology, Thessaloniki, Greece, complaining of a tumorous lesion in the anterior area of the maxilla and mild pain. Clinically, a solid in palpation lobulated tumor, covered by normal coloured mucosa was observed at the left upper incisor. After the excisional biopsy, the microscopic appearance of abundant fibromyxoid stroma, in particular, myxoid stroma intermingled with collagenous tissue, covered by stratified squamous epithelium, suggested the diagnosis of peripheral myxofibroma. During a 2-year follow-up, no recurrence was referred. This case illustrates the necessity of proper differential diagnosis of every tumorous lesion of the gingiva and of using the histopathological examination.
黏液纤维瘤（MF）是一种罕见的、非恶性的、具有潜在间充质来源的牙源性肿瘤。据估计，这种特殊肿瘤的年发病率约为每百万人口0.05例新发病例。黏液纤维瘤在10至30岁年龄范围内发病率较高。这些肿瘤在女性人群中更为常见，主要位于下颌骨，特别是后部区域。一名66岁的女性患者因上颌前部出现肿瘤性病变并伴有轻微疼痛而被转诊至希腊塞萨洛尼基的口腔外科、种植外科和放射科。临床上，在左上切牙处可触及一个质地坚硬、表面呈分叶状、被正常颜色黏膜覆盖的肿瘤。切除活检后，显微镜下可见大量纤维黏液样基质，特别是黏液样基质与胶原组织相互交织，表面覆盖有复层鳞状上皮，提示诊断为外周性黏液纤维瘤。在为期2年的随访中，未发现复发情况。该病例说明了对牙龈的每一个肿瘤性病变进行正确鉴别诊断以及进行组织病理学检查的必要性。
