Chu Zhe, Ren Qi, Chen Meizhen, Cheng Lu, Cheng Hao, Cui Wei, Bi Wenjiao, Wu Jie
Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Qingdao, China.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University Guangzhou, Guangzhou, China.
Front Bioeng Biotechnol. 2022 Aug 15;10:939129. doi: 10.3389/fbioe.2022.939129. eCollection 2022.
This study aimed to investigate the correlation of axial length/corneal radius of curvature ratio with stress-strain index (SSI). Retrospective analysis was conducted to compare the right eyes of those with high myopia (HM, n = 132; age and 10-48 years) with those without high myopia (NHM, n = 135; age and 7-48 years), where the baseline axial length, corneal radius of curvature ratio, and central corneal thickness were analyzed; the differences in two groups were compared; and the relationship of axial length and axial length/corneal radius of curvature ratio with SSI were explored. Compared with AL < 26mm, SSI significantly decreased when AL ≥ 26 mm ( = 0.001), while there was no correlation with AL in the NHM group ( = -0.14, = 0.12) or HM group ( = -0.09, = 0.32). AL/CR was significantly associated with SSI in both the NHM ( = -0.4, < 0.001) and HM ( = -0.18, = 0.04) groups. In the NHM group, AL/CR was significantly associated with SSI (unstandardized beta = -0.514, se = 0.109, < 0.001) with the adjustment of age and gender. Additionally, a significant association of SSI with AL/CR was also found after adjusting for age and gender (unstandardized beta = -0.258, se = 0.096, and = 0.0082) in the HM group. SSI showed a significant negative correlation with AL/CR in patients without high myopia and in patients with high myopia. However, SSI exhibited no decrease with the worsening of myopia, but it gradually remained stable at a low level. The findings of this study validate, to some extent, the possibility of analyzing the dynamic changes in ocular wall stiffness during the development of myopia by measuring corneal biomechanical parameters.
本研究旨在探讨眼轴长度/角膜曲率半径比值与应力应变指数（SSI）之间的相关性。进行回顾性分析，比较高度近视患者（HM，n = 132；年龄10 - 48岁）和非高度近视患者（NHM，n = 135；年龄7 - 48岁）的右眼，分析其基线眼轴长度、角膜曲率半径比值和中央角膜厚度；比较两组之间的差异；并探讨眼轴长度和眼轴长度/角膜曲率半径比值与SSI的关系。与眼轴长度（AL）< 26mm相比，当AL≥26mm时，SSI显著降低（P = 0.001），而在非高度近视组（P = -0.14，P = 0.12）或高度近视组（P = -0.09，P = 0.32）中，SSI与AL均无相关性。在非高度近视组（P = -0.4，P < 0.001）和高度近视组（P = -0.18，P = 0.04）中，AL/CR与SSI均显著相关。在非高度近视组中，调整年龄和性别后，AL/CR与SSI显著相关（非标准化β = -0.514，标准误 = 0.109，P < 0.001）。此外，在高度近视组中，调整年龄和性别后，也发现SSI与AL/CR存在显著相关性（非标准化β = -0.258，标准误 = 0.096，P = 0.0082）。在非高度近视患者和高度近视患者中，SSI与AL/CR均呈显著负相关。然而，SSI并未随近视程度的加重而降低，而是逐渐稳定在较低水平。本研究结果在一定程度上验证了通过测量角膜生物力学参数来分析近视发展过程中眼球壁硬度动态变化的可能性。
