Yin Yanchao, Fu Wei, Liu Wenhua, Li Feie, Gong Xuepeng, Liu Dong, Li Juan
Department of Pharmacy, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Clinical Research Center, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Front Pharmacol. 2023 Oct 6;14:1273020. doi: 10.3389/fphar.2023.1273020. eCollection 2023.
This study sought to analyze the leakage rate, economic loss caused by leakage, leakage reasons, and usage of upright polypropylene infusion bags and non-polyvinyl chloride (PVC) infusion bags, two types of closed intravenous infusion containers used in pharmacy intravenous admixture service (PIVAS), to improve the product quality of drug infusion packaging materials, reduce drug and clinical economic losses, and reduce the safety hazards of medication. A real-world study was used to collect statistics for these infusion containers. The study was conducted in 21 hospitals in China from September to December 2022. Upright polypropylene infusion bags or non-PVC infusion bags in PIVAS of these 21 hospitals were chosen as the research material. In total, 2,349,899 upright polypropylene infusion bags and 3,301,722 non-PVC infusion bags were collected. Eleven cases of upright polypropylene infusion bag leakage occurred (with a the leakage rate of 0.05‱), and 394 cases of non-PVC infusion bag leakage occurred (with a leakage rate of 1.19‱). The leakage rate of non-PVC infusion bags was significantly higher than that of upright polypropylene infusion bags ( < 0.01). The main reason for leakage in upright polypropylene infusion bags was sharp objects such as glass fragments or aluminum caps piercing the bag. The main reason for leakage in non-PVC infusion bags was squeezing, stacking, and uneven arrangement that causes folding of edges. For non-PVC bags, additional reasons for leakage included leakage at the nozzle joint, excessive manual or machine throwing force, and excessive dosage. The economic loss of upright polypropylene infusion bags was 1,116.56 CNY. The economic loss of non-PVC infusion bags was 32,210.86 CNY. Based on real-world study data on the leakage of upright polypropylene infusion bags and non-PVC infusion bags in multicenter PIVAS, it can be concluded that the leakage rates of upright polypropylene infusion bags are significantly lower than those of non-PVC infusion bags in PIVAS, and the economic losses due to upright polypropylene infusion bags are lower than those due to non-PVC infusion bags in PIVAS. Therefore, we can infer that upright polypropylene infusion bags are superior to non-PVC infusion bags.
本研究旨在分析直立式聚丙烯输液袋和非聚氯乙烯（PVC）输液袋这两种用于静脉药物配置中心（PIVAS）的密闭静脉输液容器的渗漏率、渗漏造成的经济损失、渗漏原因及使用情况，以提高药物输液包装材料的产品质量，减少药物及临床经济损失，降低用药安全隐患。采用真实世界研究对这些输液容器进行统计。研究于2022年9月至12月在中国的21家医院开展。选取这21家医院PIVAS中的直立式聚丙烯输液袋或非PVC输液袋作为研究材料。共收集到2349899个直立式聚丙烯输液袋和3301722个非PVC输液袋。直立式聚丙烯输液袋发生渗漏11例（渗漏率为0.05‱），非PVC输液袋发生渗漏394例（渗漏率为1.19‱）。非PVC输液袋的渗漏率显著高于直立式聚丙烯输液袋（<0.01）。直立式聚丙烯输液袋渗漏的主要原因是玻璃碎片或铝盖等尖锐物体刺破袋子。非PVC输液袋渗漏的主要原因是挤压、堆叠及摆放不均导致边缘折叠。对于非PVC袋，渗漏的其他原因包括喷嘴接头处渗漏、人工或机器投掷力过大以及剂量过大。直立式聚丙烯输液袋的经济损失为1116.56元。非PVC输液袋的经济损失为32210.86元。基于多中心PIVAS中直立式聚丙烯输液袋和非PVC输液袋渗漏情况的真实世界研究数据，可以得出结论，PIVAS中直立式聚丙烯输液袋的渗漏率显著低于非PVC输液袋，且直立式聚丙烯输液袋造成的经济损失低于非PVC输液袋。因此，可以推断直立式聚丙烯输液袋优于非PVC输液袋。
