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羟基磷灰石纳米材料的合成、表征、功能化及生物应用：概述。

Synthesis, Characterization, Functionalization and Bio-Applications of Hydroxyapatite Nanomaterials: An Overview.

机构信息

Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72388, Saudi Arabia.

Faculty of Pharmacy, University of Central Punjab, Lahore, 54000, Pakistan.

出版信息

Int J Nanomedicine. 2022 May 2;17:1903-1925. doi: 10.2147/IJN.S360670. eCollection 2022.

DOI:10.2147/IJN.S360670
PMID:35530974
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9075913/
Abstract

Hydroxyapatite (HA) is similar to natural bone regarding composition, and its structure favors in biomedical applications. Continuous research and progress on HA nanomaterials (HA-NMs) have explored novel fabrication approaches coupled with functionalization and characterization methods. These nanomaterials have a significant role in many biomedical areas like sustained drug and gene delivery, bio-imaging, magnetic resonance, cell separation, and hyperthermia treatment due to their promising biocompatibility. This review highlighted the HA-NMs chemical composition, recent progress in synthesis methods, characterization and surface modification methods, ion-doping, and role in biomedical applications. HA-NMs have a substantial role as drug delivery vehicles, coating material, bone implant, coating, ceramic, and composite materials. Here, we try to summarize an overview of HA-NMs with the provision of future directions.

摘要

羟基磷灰石（HA）在组成上与天然骨相似，其结构有利于生物医学应用。对 HA 纳米材料（HA-NMs）的持续研究和进展探索了与功能化和表征方法相结合的新型制造方法。由于其良好的生物相容性，这些纳米材料在许多生物医学领域中具有重要作用，例如持续的药物和基因递送、生物成像、磁共振、细胞分离和热疗治疗。

本篇综述强调了 HA-NMs 的化学成分、合成方法、特性和表面改性方法、离子掺杂以及在生物医学应用中的作用。HA-NMs 作为药物输送载体、涂层材料、骨植入物、涂层、陶瓷和复合材料具有重要作用。在这里，我们尝试总结 HA-NMs 的概述，并提供未来的发展方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929c/9075913/72b9c8d861ea/IJN-17-1903-g0009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929c/9075913/3633e4dc0807/IJN-17-1903-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929c/9075913/de539854c397/IJN-17-1903-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929c/9075913/72b9c8d861ea/IJN-17-1903-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929c/9075913/c4c1b44ebf05/IJN-17-1903-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929c/9075913/b84fd642d8a9/IJN-17-1903-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929c/9075913/eb9244316c4b/IJN-17-1903-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929c/9075913/068cd50f2414/IJN-17-1903-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929c/9075913/df71c6a5bffd/IJN-17-1903-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929c/9075913/39c21b8fe6f7/IJN-17-1903-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929c/9075913/3633e4dc0807/IJN-17-1903-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929c/9075913/de539854c397/IJN-17-1903-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929c/9075913/72b9c8d861ea/IJN-17-1903-g0009.jpg

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