Gbakima A A, el-Sadr W, Greene B M
Trans R Soc Trop Med Hyg. 1986;80(2):305-8. doi: 10.1016/0035-9203(86)90042-8.
The anti-microfilarial immunoglobulin response in Dirofilaria immitis infection was investigated serially in a naturally infected dog. Spontaneous clearance of microfilariae was associated with IgM opsonizing antibodies which promoted in vitro killing of microfilariae by granulocytes. Over a 6- to 11-month period, there was a shift to a predominantly IgG response. The addition of fresh non-immune serum markedly enhanced killing mediated by both IgM and IgG. The findings document conversion from IgM to IgG isotype with chronic infection, and suggest that isotype switching in canine D. immitis infection is delayed relative to that seen in bacterial or viral infections.
对一只自然感染的犬连续研究了恶丝虫感染中的抗微丝蚴免疫球蛋白反应。微丝蚴的自发清除与IgM调理抗体有关，该抗体可促进粒细胞在体外对微丝蚴的杀伤。在6至11个月的时间里，反应转变为以IgG为主。添加新鲜的非免疫血清可显著增强由IgM和IgG介导的杀伤作用。这些发现证明了慢性感染时从IgM到IgG同种型的转换，并表明犬恶丝虫感染中的同种型转换相对于细菌或病毒感染时所见的转换有所延迟。
