Meng Weiyu, Zhang Cheng, Wu Changzhe, Zhang Guanghao, Huo Xiaolin
Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, P. R. China.
School of Electrical, Electronics and Communications Engineering, University of Chinese Academy of Sciences, Beijing 100149, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2023 Oct 25;40(5):1005-1011. doi: 10.7507/1001-5515.202210012.
Transcranial electric stimulation (TES) is a non-invasive, economical, and well-tolerated neuromodulation technique. However, traditional TES is a whole-brain stimulation with a small current, which cannot satisfy the need for effectively focused stimulation of deep brain areas in clinical treatment. With the deepening of the clinical application of TES, researchers have constantly investigated new methods for deeper, more intense, and more focused stimulation, especially multi-electrode stimulation represented by high-precision TES and temporal interference stimulation. This paper reviews the stimulation optimization schemes of TES in recent years and further analyzes the characteristics and limitations of existing stimulation methods, aiming to provide a reference for related clinical applications and guide the following research on TES. In addition, this paper proposes the viewpoint of the development direction of TES, especially the direction of optimizing TES for deep brain stimulation, aiming to provide new ideas for subsequent research and application.
经颅电刺激（TES）是一种非侵入性、经济且耐受性良好的神经调节技术。然而，传统的经颅电刺激是一种小电流的全脑刺激，无法满足临床治疗中对深部脑区进行有效聚焦刺激的需求。随着经颅电刺激临床应用的不断深入，研究人员不断探索更深、更强、更聚焦刺激的新方法，尤其是以高精度经颅电刺激和时间干扰刺激为代表的多电极刺激。本文综述了近年来经颅电刺激的刺激优化方案，并进一步分析了现有刺激方法的特点和局限性，旨在为相关临床应用提供参考，并指导后续的经颅电刺激研究。此外，本文提出了经颅电刺激的发展方向观点，特别是针对深部脑刺激优化经颅电刺激的方向，旨在为后续研究和应用提供新思路。
