小蛋白与大网络相互作用。

Small protein plays with big networks.

作者信息

Tornini Valerie A

机构信息

Department of Genetics, Yale School of Medicine, New Haven, CT 06511, USA; Department of Integrative Biology and Physiology, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Institute for Society and Genetics, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.

出版信息

Trends Genet. 2024 Jan;40(1):17-19. doi: 10.1016/j.tig.2023.10.008. Epub 2023 Oct 24.

DOI:10.1016/j.tig.2023.10.008

PMID:37879968

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10847964/

Abstract

Thousands of small proteins, called microproteins, are encoded in small open reading frames (smORFs) throughout the genome. Despite assumptions that these proteins would be too small to properly fold and function, a recent study by Chen et al. identifies the surprisingly complex roles of one such microprotein.

摘要

基因组中遍布着数千种被称为微蛋白的小蛋白质，它们由小开放阅读框（smORFs）编码。尽管人们认为这些蛋白质太小，无法正确折叠和发挥功能，但陈等人最近的一项研究确定了其中一种微蛋白出人意料的复杂作用。