小蛋白与大网络相互作用。
Small protein plays with big networks.
作者信息
Tornini Valerie A
机构信息
Department of Genetics, Yale School of Medicine, New Haven, CT 06511, USA; Department of Integrative Biology and Physiology, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Institute for Society and Genetics, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
出版信息
Trends Genet. 2024 Jan;40(1):17-19. doi: 10.1016/j.tig.2023.10.008. Epub 2023 Oct 24.
Abstract
Thousands of small proteins, called microproteins, are encoded in small open reading frames (smORFs) throughout the genome. Despite assumptions that these proteins would be too small to properly fold and function, a recent study by Chen et al. identifies the surprisingly complex roles of one such microprotein.
摘要
基因组中遍布着数千种被称为微蛋白的小蛋白质，它们由小开放阅读框（smORFs）编码。尽管人们认为这些蛋白质太小，无法正确折叠和发挥功能，但陈等人最近的一项研究确定了其中一种微蛋白出人意料的复杂作用。
相似文献
1
Small protein plays with big networks.小蛋白与大网络相互作用。
Trends Genet. 2024 Jan;40(1):17-19. doi: 10.1016/j.tig.2023.10.008. Epub 2023 Oct 24.
2
Integrated workflow for discovery of microprotein-coding small open reading frames.微蛋白编码小开放阅读框发现的综合工作流程。
STAR Protoc. 2023 Dec 15;4(4):102649. doi: 10.1016/j.xpro.2023.102649. Epub 2023 Oct 23.
3
Enrichment-Based Proteogenomics Identifies Microproteins, Missing Proteins, and Novel smORFs in Saccharomyces cerevisiae.基于富集的蛋白质基因组学鉴定酿酒酵母中的微蛋白、缺失蛋白和新型 smORFs。
J Proteome Res. 2018 Jul 6;17(7):2335-2344. doi: 10.1021/acs.jproteome.8b00032. Epub 2018 Jun 25.
4
smORFunction: a tool for predicting functions of small open reading frames and microproteins.smORFunction：一种预测小开放阅读框和微蛋白功能的工具。
BMC Bioinformatics. 2020 Oct 14;21(1):455. doi: 10.1186/s12859-020-03805-x.
5
Pervasiveness of Microprotein Function Amongst Small Open Reading Frames (SMORFS).小开放阅读框（SMORFS）中微蛋白功能的普遍性
Cells. 2024 Dec 18;13(24):2090. doi: 10.3390/cells13242090.
6
Microprotein-encoding RNA regulation in cells treated with pro-inflammatory and pro-fibrotic stimuli.在受到促炎和促纤维化刺激的细胞中，微小蛋白编码 RNA 的调控。
BMC Genomics. 2024 Nov 5;25(1):1034. doi: 10.1186/s12864-024-10948-1.
7
Microproteins: a 3D protein structure prediction analysis.微蛋白：三维蛋白质结构预测分析。
J Biomol Struct Dyn. 2022;40(24):13738-13746. doi: 10.1080/07391102.2021.1993343. Epub 2021 Oct 27.
8
Small ORFs, Big Insights: as a Model to Unraveling Microprotein Functions.小开放阅读框，大发现：作为揭示微小蛋白质功能的模型。
Cells. 2024 Oct 2;13(19):1645. doi: 10.3390/cells13191645.
9
Ribosome profiling reveals hidden world of small proteins.核糖体分析揭示了小蛋白的隐秘世界。
Trends Genet. 2025 Feb;41(2):101-103. doi: 10.1016/j.tig.2024.12.010. Epub 2025 Jan 14.
10
Accurate annotation of human protein-coding small open reading frames.准确注释人类蛋白质编码的小开放阅读框。
Nat Chem Biol. 2020 Apr;16(4):458-468. doi: 10.1038/s41589-019-0425-0. Epub 2019 Dec 9.
本文引用的文献
1
Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5.未注释的微蛋白 EMBOW 调节 WDR5 的互作组、染色质和有丝分裂功能。
Cell Rep. 2023 Sep 26;42(9):113145. doi: 10.1016/j.celrep.2023.113145. Epub 2023 Sep 19.
2
and encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells.并编码微肽，调节脊椎动物特异性神经细胞中的染色质可及性。
Elife. 2023 May 16;12:e82249. doi: 10.7554/eLife.82249.
3
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames.人类、年轻微蛋白和小肽的进化起源和互作组，这些微蛋白和小肽是由短开放阅读框翻译而来的。
Mol Cell. 2023 Mar 16;83(6):994-1011.e18. doi: 10.1016/j.molcel.2023.01.023. Epub 2023 Feb 17.
4
Developmental dynamics of RNA translation in the human brain.人类大脑中 RNA 翻译的发育动力学。
Nat Neurosci. 2022 Oct;25(10):1353-1365. doi: 10.1038/s41593-022-01164-9. Epub 2022 Sep 28.
5
Standardized annotation of translated open reading frames.翻译后的开放阅读框的标准化注释。
Nat Biotechnol. 2022 Jul;40(7):994-999. doi: 10.1038/s41587-022-01369-0.
6
: Umbrella Gene for Multiple Diseases.多疾病的伞基因。
Genes (Basel). 2022 Mar 15;13(3):514. doi: 10.3390/genes13030514.
7
Early loss of Scribble affects cortical development, interhemispheric connectivity and psychomotor activity.Scribble 的早期缺失会影响皮质发育、大脑两半球间的连通性和精神运动活动。
Sci Rep. 2021 Apr 27;11(1):9106. doi: 10.1038/s41598-021-88147-1.
8
Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation.利用核糖体足迹法和进化保守性鉴定脊椎动物中的小开放阅读框。
EMBO J. 2014 May 2;33(9):981-93. doi: 10.1002/embj.201488411. Epub 2014 Apr 4.
9
Peptidomic discovery of short open reading frame-encoded peptides in human cells.人类细胞中短开放阅读框编码肽的肽组学发现。
Nat Chem Biol. 2013 Jan;9(1):59-64. doi: 10.1038/nchembio.1120. Epub 2012 Nov 18.
10
Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling.使用核糖体谱分析在体内以核苷酸分辨率进行全基因组翻译分析。
Science. 2009 Apr 10;324(5924):218-23. doi: 10.1126/science.1168978. Epub 2009 Feb 12.
Zotero 插件