Department of Sport Sciences, Shiraz University, Shiraz, Iran.
Organ Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Res Sports Med. 2022 Jan-Feb;30(1):80-91. doi: 10.1080/15438627.2021.1906671. Epub 2021 Apr 11.
The purpose of this study was to investigate the effects of a 12 week exercise training on the immune system of kidney transplant recipients. 23 kidney transplant recipients were randomly divided into two groups including control (n = 10) and training (n =13) groups. The training groups participated in the training for 10 weeks (three days a week; each day 60-90 minutes). The control group performed no regular exercise during this time. The blood samples were taken before and after 12 weeks. ELISA and Real-time PCR were used to evaluate cytokine profiles, including TNF-a, IL-6, IL-4, IL-31 and IL-35 as well as T-bet, GATA-3, RORYt and FOXP3, respectively. Finally, the data were analyzed, using paired T-test. ELISA results showed decreased levels of TNF- α, increased levels of IL-6 and no significant differences in the IL-35, IL-31 and IL-4 levels in the training group in comparison to the control group. Gene expression profiles showed significantly increased expression of T-bet and no changes in the GATA-3, RORYt and FOXP3 levels. According to these results, a moderate exercise including aerobic and resistance training could inhibit inflammatory cytokines and have beneficial effects on the immune system, but this issue needs further research.
本研究旨在探讨为期 12 周的运动训练对肾移植受者免疫系统的影响。23 名肾移植受者随机分为两组，包括对照组（n=10）和训练组（n=13）。训练组进行了 10 周的训练（每周 3 天；每天 60-90 分钟）。对照组在此期间不进行常规运动。在 12 周前后采集血液样本。采用 ELISA 和实时 PCR 评估细胞因子谱，包括 TNF-a、IL-6、IL-4、IL-31 和 IL-35 以及 T-bet、GATA-3、RORYt 和 FOXP3。最后，使用配对 t 检验对数据进行分析。ELISA 结果显示，与对照组相比，训练组 TNF-α 水平降低，IL-6 水平升高，而 IL-35、IL-31 和 IL-4 水平无显著差异。基因表达谱显示 T-bet 表达显著增加，而 GATA-3、RORYt 和 FOXP3 水平无变化。根据这些结果，中等强度的运动训练包括有氧运动和抗阻训练可以抑制炎症细胞因子，并对免疫系统产生有益影响，但这一问题需要进一步研究。
