Jiang Luo, Gong Ting-Ting, Gao Song, Li Xiu-Qin, Liu Fang-Hua, Wen Zhao-Yan, Wei Yi-Fan, Yan Shi, Hou Rui, Wu Qi-Jun
Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Front Nutr. 2021 Oct 29;8:750801. doi: 10.3389/fnut.2021.750801. eCollection 2021.
Dairy product consumption is associated with ovarian cancer (OC) incidence. However, limited evidence is available on its influence on OC mortality. The association between pre-diagnostic dairy product intake and OC mortality was investigated in the OC follow-up study, which included a hospital-based cohort ( = 853) of women diagnosed with epithelial OC between 2015 and 2020. Pre-diagnosis diet information was collected using a validated food frequency questionnaire. Deaths were ascertained up to March 31, 2021 via death registry linkage. Cox proportional hazards model was used to estimate the adjusted hazard ratio (HR) and 95% confidence interval (CI) for the aforementioned association. A total of 130 women died during the median follow-up of 37.2 months (interquartile: 24.7-50.2 months). Comparisons of highest to lowest tertile intake showed that pre-diagnosis dairy product use was associated with total OC mortality (HR = 2.03, 95% CI = 1.21-3.40, trend = 0.06). In addition, short survival was separately associated with protein (HR = 2.09, 95% CI = 1.25-3.49, trend < 0.05), fat (HR = 2.16, 95% CI = 1.30-3.61, trend < 0.05), and calcium (HR = 2.03, 95% CI = 1.21-3.4, trend = 0.06) from dairy intake. Similar positive magnitudes were observed for menopausal status, residual lesions, histological type, and body mass index, although not all of these factors showed statistical significance. Pre-diagnosis dairy product consumption, including protein, fat, and calcium from dairy intake, was associated with higher mortality among OC survivors.
乳制品消费与卵巢癌（OC）发病率相关。然而，关于其对OC死亡率影响的证据有限。在OC随访研究中调查了诊断前乳制品摄入量与OC死亡率之间的关联，该研究纳入了一个基于医院的队列（n = 853），这些女性在2015年至2020年间被诊断为上皮性OC。使用经过验证的食物频率问卷收集诊断前饮食信息。通过死亡登记联动确定截至2021年3月31日的死亡情况。采用Cox比例风险模型估计上述关联的调整风险比（HR）和95%置信区间（CI）。在37.2个月的中位随访期（四分位间距：24.7 - 50.2个月）内，共有130名女性死亡。最高三分位数摄入量与最低三分位数摄入量的比较表明，诊断前乳制品的摄入与OC总死亡率相关（HR = 2.03，95% CI = 1.21 - 3.40，P趋势 = 0.06）。此外，生存期短分别与乳制品摄入中的蛋白质（HR = 2.09，95% CI = 1.25 - 3.49，P趋势 < 0.05）、脂肪（HR = 2.16，95% CI = 1.30 - 3.61，P趋势 < 0.05）和钙（HR = 2.03，95% CI = 1.21 - 3.4，P趋势 = 0.06）相关。对于绝经状态、残留病灶、组织学类型和体重指数，观察到类似程度的正相关，尽管并非所有这些因素都具有统计学意义。诊断前乳制品消费，包括乳制品摄入中的蛋白质、脂肪和钙，与OC幸存者较高的死亡率相关。
