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解析高尔基体的多方面作用:对神经元可塑性、发育、神经发生、阿尔茨海默病及新型冠状病毒2019(SARS-CoV-2)相互作用的见解

Unraveling the Multifaceted Role of the Golgi Apparatus: Insights into Neuronal Plasticity, Development, Neurogenesis, Alzheimer's Disease, and SARS-CoV-2 Interactions.

作者信息

Toader Corneliu, Eva Lucian, Covache-Busuioc Razvan-Adrian, Costin Horia Petre, Glavan Luca-Andrei, Corlatescu Antonio Daniel, Ciurea Alexandru Vlad

机构信息

Department of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases, 077160 Bucharest, Romania.

出版信息

Brain Sci. 2023 Sep 23;13(10):1363. doi: 10.3390/brainsci13101363.

Abstract

This article critically evaluates the multifunctional role of the Golgi apparatus within neurological paradigms. We succinctly highlight its influence on neuronal plasticity, development, and the vital trafficking and sorting mechanisms for proteins and lipids. The discourse further navigates to its regulatory prominence in neurogenesis and its implications in Alzheimer's Disease pathogenesis. The emerging nexus between the Golgi apparatus and SARS-CoV-2 underscores its potential in viral replication processes. This consolidation accentuates the Golgi apparatus's centrality in neurobiology and its intersections with both neurodegenerative and viral pathologies. In essence, understanding the Golgi's multifaceted functions harbors profound implications for future therapeutic innovations in neurological and viral afflictions.

摘要

本文批判性地评估了高尔基体在神经学范式中的多功能作用。我们简要强调了它对神经元可塑性、发育以及蛋白质和脂质的重要运输和分选机制的影响。论述进一步探讨了它在神经发生中的调节重要性及其在阿尔茨海默病发病机制中的意义。高尔基体与严重急性呼吸综合征冠状病毒2(SARS-CoV-2)之间新出现的联系突出了其在病毒复制过程中的潜力。这种整合突出了高尔基体在神经生物学中的核心地位及其与神经退行性疾病和病毒病理学的交叉点。从本质上讲,了解高尔基体的多方面功能对神经和病毒疾病未来的治疗创新具有深远意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c244/10605100/9a4e6f3f3a31/brainsci-13-01363-g001.jpg

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