Pivac Ivan, Jelicic Kadic Antonia, Despot Ranka, Zitko Vanda, Tudor Darija, Runjic Edita, Markic Josko
School of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia.
Department of Pediatrics, University Hospital of Split, Spinciceva 1, 21000 Split, Croatia.
Children (Basel). 2023 Oct 11;10(10):1677. doi: 10.3390/children10101677.
Inflammatory bowel diseases (IBDs), encompassing ulcerative colitis (UC) and Crohn's disease (CD), are chronic gastrointestinal disorders often diagnosed in youth, presenting unique features compared to adult-onset cases. We aimed to profile pediatric IBD patients in Croatia through a retrospective analysis of children up to 18 years old diagnosed with IBD at the University Hospital of Split from 1 January 2012, to 31 December 2021, utilizing data collected during hospitalization for diagnosis. Over a decade, 107 children were diagnosed, with 43.9% having UC, 55.1% CD, and 0.9% IBD-unclassified. Median age at diagnosis was 14.1 years, with UC patients being older (14.8 vs. 13.7 years, = 0.044). Males constituted 60.7% of patients. Median symptom duration was 2.0 months, with CD patients experiencing a longer diagnostic delay (3.0 vs. 2.0 months, = 0.003). The median incidence rate was 9.89 (95% CI 5.93-13.84) per 100,000 children/year, varying across age groups. Median (IQR) BMI z-score was -0.34 (-0.97-0.45). Common symptoms included diarrhea (60.7%) and abdominal pain (50.5%), with rectal bleeding more prevalent in UC (72.3% vs. 32.2%, < 0.001). While our study offers valuable insights into pediatric IBD in Croatia, further prospective research is needed to clarify disease progression and development.
炎症性肠病（IBD）包括溃疡性结肠炎（UC）和克罗恩病（CD），是一种慢性胃肠道疾病，常在青少年时期被诊断出来，与成人发病的病例相比具有独特的特征。我们旨在通过对2012年1月1日至2021年12月31日期间在斯普利特大学医院被诊断为IBD的18岁以下儿童进行回顾性分析，利用诊断住院期间收集的数据，对克罗地亚的儿科IBD患者进行分析。在十年间，共诊断出107名儿童，其中43.9%患有UC，55.1%患有CD，0.9%为未分类的IBD。诊断时的中位年龄为14.1岁，UC患者年龄较大（14.8岁对13.7岁，P = 0.044）。男性占患者的60.7%。中位症状持续时间为2.0个月，CD患者的诊断延迟更长（3.0个月对2.0个月，P = 0.003）。每10万名儿童/年的中位发病率为9.89（95%CI 5.93 - 13.84），各年龄组有所不同。中位（IQR）BMI z评分是 -0.34（-0.97 - 0.45）。常见症状包括腹泻（60.7%）和腹痛（50.5%），直肠出血在UC中更常见（72.3%对32.2%，P < 0.001）。虽然我们的研究为克罗地亚的儿科IBD提供了有价值的见解，但仍需要进一步的前瞻性研究来阐明疾病的进展和发展。
