癸酸与冠状动脉疾病的关系：基于人群的横断面研究。
Relationship between Dietary Decanoic Acid and Coronary Artery Disease: A Population-Based Cross-Sectional Study.
机构信息
Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Department of Respiratory Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
出版信息
Nutrients. 2023 Oct 10;15(20):4308. doi: 10.3390/nu15204308.
BACKGROUND
Coronary artery disease (CAD) is a cardiovascular disease with significant personal health and socioeconomic consequences. The biological functions of decanoic acid and the pathogenesis of CAD overlap considerably; however, studies exploring their relationship are limited.
METHODS
Data from 34,186 Americans from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2018 were analyzed. The relationship between dietary decanoic acid (DDA) and CAD prevalence was explored using weighted multivariate logistic regression models, generalized summation models, and fitted smoothing curves. Stratified analyses and interaction tests were conducted to explore the potential modifiers between them.
RESULTS
DDA was negatively associated with CAD prevalence, with each 1 g/d increase in the DDA being associated with a 21% reduction in CAD prevalence (odds ratio (OR) 0.79, 95% confidence interval (CI) 0.61-1.02). This relationship persisted after log10 and trinomial transformations, respectively. The OR after log10 transformation was 0.81 (95% CI 0.69-0.96), and the OR for tertile 3 compared with tertile 1 was 0.83 (95% CI 0.69-1.00). The subgroup analyses found this relationship to be significant among males and non-Hispanic white individuals, and there was a significant interaction (interaction -values of 0.011 and 0.012, respectively).
CONCLUSIONS
DDA was negatively associated with the prevalence of CAD, and both sex and race may modify this relationship.
背景
冠心病（CAD）是一种心血管疾病，对个人健康和社会经济都有重大影响。癸酸的生物学功能与 CAD 的发病机制有很大的重叠；然而，探索它们之间关系的研究是有限的。
方法
分析了 2003 年至 2018 年来自美国国家健康和营养检查调查（NHANES）的 34186 名美国人的数据。使用加权多变量逻辑回归模型、广义求和模型和拟合平滑曲线来探讨膳食癸酸（DDA）与 CAD 患病率之间的关系。进行分层分析和交互检验，以探讨它们之间潜在的修饰因子。
结果
DDA 与 CAD 患病率呈负相关，DDA 每增加 1 g/d，CAD 患病率降低 21%（比值比（OR）0.79，95%置信区间（CI）0.61-1.02）。这种关系在对数 10 和三进制转换后仍然存在。对数 10 转换后的 OR 为 0.81（95%CI 0.69-0.96），与 tertile 1 相比， tertile 3 的 OR 为 0.83（95%CI 0.69-1.00）。亚组分析发现，这种关系在男性和非西班牙裔白种人群中具有统计学意义，且存在显著的交互作用（交互作用的 -值分别为 0.011 和 0.012）。
结论
DDA 与 CAD 患病率呈负相关，性别和种族可能会调节这种关系。
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