Ergun Gokhan, Demirelli Selami
Department of Cardiology, Kayseri City Training and Research Hospital, 38080 Kayseri, Turkey.
J Clin Med. 2023 Oct 10;12(20):6440. doi: 10.3390/jcm12206440.
The exercise electrocardiography test (EET) is still used before coronary angiography in the diagnosis of chronic coronary syndromes. This study aimed to demonstrate the value of the combination of a positive EET with the systemic inflammatory index (SII), the plasma atherogenic index (PAI), and the monocyte/HDL-C ratio (MHR) in the determination of obstructive coronary artery disease (CAD). This single-center, retrospective study included 540 patients who underwent coronary angiography after ETT. The patients were separated into Group 1, comprising 434 patients with normal coronary arteries and non-obstructive CAD, and Group 2, including 106 with obstructive CAD. In Group 2, the patients were separated into SYNTAX ≤ 22 or ≥23. Glucose, low-density lipoprotein, white blood cells, and MHR were determined to be significantly higher in Group 2 ( < 0.05). According to the multivariate logistic regression analysis, age, gender, diabetes mellitus, and low-density lipoprotein were determined to be independent predictors of CAD. In the ROC curve analysis, a cut-off value of 12 for the MHR in the determination of obstructive CAD had a sensitivity of 60.4% and a specificity of 53.0%. The main result of this study was that a high MHR is an indicator of obstructive CAD in patients with positive EET and suspected CAD.
运动心电图测试（EET）在冠状动脉造影之前仍被用于慢性冠状动脉综合征的诊断。本研究旨在证明EET阳性与全身炎症指数（SII）、血浆致动脉粥样硬化指数（PAI）以及单核细胞/高密度脂蛋白胆固醇比值（MHR）相结合在确定阻塞性冠状动脉疾病（CAD）方面的价值。这项单中心回顾性研究纳入了540例在运动心电图测试（ETT）后接受冠状动脉造影的患者。患者被分为两组，第1组包括434例冠状动脉正常和非阻塞性CAD患者，第2组包括106例阻塞性CAD患者。在第2组中，患者又被分为SYNTAX评分≤22或≥23。结果发现，第2组患者的血糖、低密度脂蛋白、白细胞和MHR显著更高（<0.05）。根据多因素逻辑回归分析，年龄、性别、糖尿病和低密度脂蛋白被确定为CAD的独立预测因素。在ROC曲线分析中，MHR在确定阻塞性CAD时的截断值为12，其敏感性为60.4%，特异性为53.0%。本研究的主要结果是，高MHR是EET阳性且疑似CAD患者阻塞性CAD的一个指标。
