Dybciak Paweł, Raczkiewicz Dorota, Humeniuk Ewa, Powrózek Tomasz, Gujski Mariusz, Małecka-Massalska Teresa, Wdowiak Artur, Bojar Iwona
Centre of Postgraduate Medical Education, Marymoncka Street 99/103, 01-813 Warsaw, Poland.
Department of Medical Statistics, School of Public Health, Centre of Postgraduate Medical Education, Kleczewska 61/63 Street, 01-826 Warsaw, Poland.
J Clin Med. 2023 Oct 10;12(20):6446. doi: 10.3390/jcm12206446.
Polycystic ovary syndrome (PCOS) is an endocrine disorder with a broad spectrum of clinical symptoms. Some of the serious complications of PCOS are mental disorders including depression. Therefore, the aim of the meta-analysis was to determine the prevalence, mean level, standardized mean difference and probability of depression based on the research conducted with the Hospital Anxiety and Depression Scale (HADS). A systematic literature search was performed using the following databases: PubMed, EMBASE, Scopus, ClinicalTrials.gov and Google for research published until January 2023. The meta-analysis was conducted on a group of 4002 patients obtained from 19 studies, which met the inclusion criteria (adult pre-menopausal women diagnosed with PCOS, papers on the prevalence of depression or the HADS scoring). According to the research performed, the mean prevalence of depression was 31% (I2 = 93%; < 0.001), whereas the mean HADS depression score in patients with PCOS was 6.31 (I2 = 93%; < 0.001). The standardized difference of mean depression scores was SMD = 0.421 (95% confidence interval = 0.17-0.68, I2 = 67%). The overall probability of depression in PCOS patients was more than 2.5-fold higher than in healthy women ((RR: 2.58), confidence interval [1.38-4.85]; I2 = 90%, < 0.001). The research results imply an increased risk of depressive symptoms in women with PCOS.
多囊卵巢综合征（PCOS）是一种具有广泛临床症状的内分泌紊乱疾病。PCOS的一些严重并发症是包括抑郁症在内的精神障碍。因此，本荟萃分析的目的是根据使用医院焦虑抑郁量表（HADS）进行的研究，确定抑郁症的患病率、平均水平、标准化平均差和概率。使用以下数据库进行了系统的文献检索：PubMed、EMBASE、Scopus、ClinicalTrials.gov和谷歌，检索截至2023年1月发表的研究。对从19项研究中获得的4002名患者进行了荟萃分析，这些研究符合纳入标准（诊断为PCOS的成年绝经前女性、关于抑郁症患病率或HADS评分的论文）。根据所进行的研究，抑郁症的平均患病率为31%（I2 = 93%；P < 0.001），而PCOS患者的平均HADS抑郁评分为6.31（I2 = 93%；P < 0.001）。平均抑郁评分的标准化差异为SMD = 0.421（95%置信区间 = 0.17 - 0.68，I2 = 67%）。PCOS患者患抑郁症的总体概率比健康女性高2.5倍以上（（RR：2.58），置信区间[1.38 - 4.85]；I2 = 90%，P < 0.001）。研究结果表明PCOS女性出现抑郁症状的风险增加。
