Korzeń Dariusz, Sierka Oskar, Dąbek Józefa
Provincial Specialist Hospital Megrez Sp. z o. o., Edukacji Street 102, 43-100 Tychy, Poland.
Student Research Group at the Department of Cardiology, Department of Cardiology, Faculty of Health Sciences in Katowice, Medical University of Silesia in Katowice, Ziołowa Street 45/47, 40-635 Katowice, Poland.
Biomedicines. 2023 Oct 13;11(10):2776. doi: 10.3390/biomedicines11102776.
The most common cause of heart failure (HF) is coronary artery disease (CAD). The aim of this study was to evaluate the transcriptional activity of the () and () genes in a study group of patients with HF due to CAD and in the control group, as well as assess the transcriptional activity of the examined genes, taking into account the number of affected coronary arteries and the severity of heart failure. The study group consisted of a total of 150 (100%) patients. The material for the study was peripheral blood, and molecular tests were performed using the quantitative QRT-PCR technique. The transcriptional activity of the gene was significantly higher in the group of patients with CAD and HF. It was also significantly higher with the progression of heart failure. gene transcriptional activity was significantly lower with the advancement of heart failure. The transcriptional activity of the and genes differentiated the examined patients. The severity of HF, and a significant increase in the QRT-PCR transcriptional activity of the gene with a simultaneous decrease in the activity of the gene, makes them useful diagnostic and prognostic markers in clinical practice.
心力衰竭（HF）最常见的病因是冠状动脉疾病（CAD）。本研究的目的是评估因CAD导致HF的研究组患者和对照组中（）基因和（）基因的转录活性，并考虑受影响冠状动脉的数量和心力衰竭的严重程度来评估所检测基因的转录活性。研究组共有150名（100%）患者。研究材料为外周血，分子检测采用定量QRT-PCR技术。CAD合并HF患者组中基因的转录活性显著更高。随着心力衰竭的进展，其转录活性也显著升高。随着心力衰竭的进展，基因转录活性显著降低。基因和基因的转录活性区分了所检测的患者。HF的严重程度，以及基因QRT-PCR转录活性的显著增加同时基因活性的降低，使其在临床实践中成为有用的诊断和预后标志物。
