Barbosa Filipe, Dueñas-Pamplona Jorge, Abreu Cristiano S, Oliveira Mónica S N, Lima Rui A
Mechanical Engineering and Resource Sustainability Center (METRICS), University of Minho, 4800-058 Guimarães, Portugal.
Departamento de Ingeniería Energética, Universidad Politécnica de Madrid, 28040 Madrid, Spain.
Micromachines (Basel). 2023 Sep 30;14(10):1886. doi: 10.3390/mi14101886.
A computational fluid dynamics (CFD) model of blood flow through hyperbolic contraction with a discrete phase model (DPM) was experimentally validated. For this purpose, the positions and velocities of red blood cells (RBCs) flowing in a microchannel with hyperbolic contraction were experimentally assessed using image analysis techniques, and were subsequently compared with the numerical results. The numerically and experimentally obtained velocity fields were in good agreement, with errors smaller than 10%. Additionally, a nearly constant strain rate was observed in the contraction region, which can be attributed to the quasilinear increase in the velocity along the hyperbolic contraction. Therefore, the numerical technique used was validated due to the close similarity between the numerically and experimentally obtained results. The tested CFD model can be used to optimize the microchannel design by minimizing the need to fabricate prototypes and evaluate them experimentally.
通过离散相模型（DPM）对血液流经双曲线收缩的计算流体动力学（CFD）模型进行了实验验证。为此，利用图像分析技术对在具有双曲线收缩的微通道中流动的红细胞（RBC）的位置和速度进行了实验评估，并随后与数值结果进行了比较。数值和实验获得的速度场吻合良好，误差小于10%。此外，在收缩区域观察到几乎恒定的应变率，这可归因于沿双曲线收缩速度的准线性增加。因此，由于数值和实验结果非常相似，所使用的数值技术得到了验证。经过测试的CFD模型可用于优化微通道设计，从而减少制造原型并进行实验评估的需求。
