Zhou Fuchen, Quan Jianping, Ruan Donglin, Qiu Yibin, Ding Rongrong, Xu Cineng, Ye Yong, Cai Gengyuan, Liu Langqing, Zhang Zebin, Yang Jie, Wu Zhenfang, Zheng Enqin
College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.
Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, South China Agricultural University, Guangzhou 510642, China.
Animals (Basel). 2023 Oct 18;13(20):3243. doi: 10.3390/ani13203243.
During the process of pork production, the carcasses of pigs are divided and sold, which provides better economic benefits and market competitiveness for pork production than selling the carcass as a whole. Due to the significant cost of post-slaughter phenotypic measurement, the genetic architecture of tenderloin weight (TLNW) and rib weight (RIBW)-important components of pig carcass economic value-remain unknown. In this study, we conducted genome-wide association studies (GWAS) for TLNW and RIBW traits in a population of 431 Duroc × Landrace × Yorkshire (DLY) pigs. In our study, the most significant single nucleotide polymorphism (SNP) associated with TLNW was identified as ASGA0085853 (3.28 Mb) on Sus scrofa chromosome 12 (SSC12), while for RIBW, it was Affx-1115046258 (172.45 Mb) on SSC13. Through haplotype block analysis, we discovered a novel quantitative trait locus (QTL) associated with TLNW, spanning a 5 kb region on SSC12, and a novel RIBW-associated QTL spanning 1.42 Mb on SSC13. Furthermore, we hypothesized that three candidate genes, and , and , are associated with TLNW and RIBW, respectively. Our research not only addresses the knowledge gap regarding TLNW, but also serves as a valuable reference for studying RIBW. The identified SNP loci strongly associated with TLNW and RIBW may prove useful for marker-assisted selection in pig breeding programs.
在猪肉生产过程中，猪胴体被分割出售，这比整只出售胴体为猪肉生产带来了更好的经济效益和市场竞争力。由于屠宰后表型测量成本高昂，猪胴体经济价值的重要组成部分——里脊肉重量（TLNW）和肋骨重量（RIBW）的遗传结构仍不清楚。在本研究中，我们对431头杜洛克×长白×大白（DLY）猪群体的TLNW和RIBW性状进行了全基因组关联研究（GWAS）。在我们的研究中，与TLNW相关的最显著单核苷酸多态性（SNP）被确定为猪12号染色体（SSC12）上的ASGA0085853（3.28 Mb），而对于RIBW，是SSC13上的Affx-1115046258（172.45 Mb）。通过单倍型块分析，我们发现了一个与TLNW相关的新数量性状位点（QTL），位于SSC12上一个5 kb的区域，以及一个与RIBW相关的新QTL，位于SSC13上跨度为1.42 Mb的区域。此外，我们假设三个候选基因，以及，和，分别与TLNW和RIBW相关。我们的研究不仅填补了关于TLNW的知识空白，也为研究RIBW提供了有价值的参考。所确定的与TLNW和RIBW密切相关的SNP位点可能对猪育种计划中的标记辅助选择有用。
