Szczepanik Kinga, Oczkowicz Maria, Dobrowolski Piotr, Świątkiewicz Małgorzata
Department of Animal Nutrition and Feed Science, National Research Institute of Animal Production, Krakowska St. 1, 32-083 Balice, Poland.
Department of Animal Molecular Biology, National Research Institute of Animal Production, Krakowska St. 1, 32-083 Balice, Poland.
Animals (Basel). 2023 Oct 19;13(20):3268. doi: 10.3390/ani13203268.
During the weaning period, piglets are exposed to high levels of stress, which often causes problems with the digestive system. This stress also promotes the production of free radicals, resulting in oxidative stress. Astaxanthin (AST) stands out as one of the most potent antioxidants. Its resistance to light and heat makes it particularly valuable in compound feed production. This study was to determine the effect of AST impact on liver histology and gene expression in piglets. For our experiment, we used 16 weaned piglets of the PL breed, which we divided into two groups: Group I (control group with no AST supplementation) and Group II (supplemented with AST at 0.025 g/kg). Both feed mixtures were iso-proteins and iso-energetic, meeting the nutritional requirements of the piglets. The experiment lasted from day 35 to day 70 of the piglets' age, during which they had ad libitum access. The results indicate that the addition of AST prevents liver fibrosis due to reduced collagen deposition in the tissue. Analysis of gene expression supported these results. In the AST-supplemented group, we noted a decrease in expression, an increase in expression, and reductions in the expression of and genes.
在断奶期，仔猪面临高水平应激，这常常导致消化系统出现问题。这种应激还会促进自由基的产生，从而导致氧化应激。虾青素（AST）是最有效的抗氧化剂之一。其对光和热的耐受性使其在复合饲料生产中特别有价值。本研究旨在确定AST对仔猪肝脏组织学和基因表达的影响。在我们的实验中，我们使用了16头PL品种的断奶仔猪，将其分为两组：第一组（不添加AST的对照组）和第二组（添加0.025 g/kg AST）。两种饲料混合物都是等蛋白和等能量的，满足仔猪的营养需求。实验从仔猪35日龄持续到70日龄，在此期间仔猪可自由采食。结果表明，添加AST可防止肝脏纤维化，因为组织中胶原蛋白沉积减少。基因表达分析支持了这些结果。在添加AST的组中，我们注意到 表达下降， 表达增加，以及 和 基因的表达减少。
